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Submit ReviewAspirin
Description: Cyclooxygenase inhibitor; NSAID
Chemical Name: 2-Acetoxybenzoic acid
Purity: ≥99% (HPLC)
Biological Activity
Inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
Compound Libraries
Aspirin is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 180.16 |
| Formula | C9H8O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 50-78-2 |
| PubChem ID | 2244 |
| InChI Key | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
| Smiles | CC(OC1=C(C(O)=O)C=CC=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.8 | 10 | |
| DMSO | 18.02 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 180.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.55 mL | 27.75 mL | 55.51 mL |
| 5 mM | 1.11 mL | 5.55 mL | 11.1 mL |
| 10 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 50 mM | 0.11 mL | 0.56 mL | 1.11 mL |
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References
References are publications that support the biological activity of the product.
Schror (1997) Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin.Thromb.Hemost. 23 349 PMID: 9263351
Sanduja et al (1991) Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc.Natl.Acad.Sci. 15 88
Baron (1995) Aspirin and cancer. Preventative Medicine 24 121
If you know of a relevant reference for Aspirin, please let us know.
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Keywords: Aspirin, Aspirin supplier, cyclooxygenase, inhibitors, inhibits, antithrombotic, antiplatelet, NSAID, prostaglandin, H, synthase, blocks, thromboxane, synthesis, Cyclooxygenase, 4092, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Aspirin (NOTE: It is especially important not to use aspirin during the last three months of pregnancy, unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.), which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
2 Citations for Aspirin
Citations are publications that use Tocris products. Selected citations for Aspirin include:
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
Do you know of a great paper that uses Aspirin from Tocris? Please let us know.
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