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Biological Activity for Aspirin
Aspirin is an inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
Compound Libraries for Aspirin
Technical Data for Aspirin
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Aspirin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Aspirin
The following data is based on the product molecular weight 180.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.55 mL||27.75 mL||55.51 mL|
|5 mM||1.11 mL||5.55 mL||11.1 mL|
|10 mM||0.56 mL||2.78 mL||5.55 mL|
|50 mM||0.11 mL||0.56 mL||1.11 mL|
References for Aspirin
References are publications that support the biological activity of the product.
Schror (1997) Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin.Thromb.Hemost. 23 349 PMID: 9263351
Wu et al (1991) Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc.Natl.Acad.Sci.U.S.A. 15 88 PMID: 1900943
Baron (1995) Aspirin and cancer. Preventative Medicine 24 121 PMID: 7597012
If you know of a relevant reference for Aspirin, please let us know.
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Keywords: Aspirin, Aspirin supplier, cyclooxygenase, inhibitors, inhibits, antithrombotic, antiplatelet, NSAID, prostaglandin, H, synthase, blocks, thromboxane, synthesis, Cyclooxygenase, 4092, Tocris Bioscience
2 Citations for Aspirin
Citations are publications that use Tocris products. Selected citations for Aspirin include:
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178 PMID: 24494191
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249 PMID: 24258815
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Literature in this Area
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