SC 560

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Cat.No. 1550 - SC 560 | C17H12ClF3N2O | CAS No. 188817-13-2
Description: Cyclooxygenase-1 (COX-1) inhibitor
Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Compound Libraries

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Technical Data

M. Wt 352.74
Formula C17H12ClF3N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 188817-13-2
PubChem ID 4306515
InChI Key PQUGCKBLVKJMNT-UHFFFAOYSA-N
Smiles COC1=CC=C(C=C1)N1N=C(C=C1C1=CC=C(Cl)C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.27 100
ethanol 8.82 25

Preparing Stock Solutions

The following data is based on the product molecular weight 352.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.17 mL 28.35 mL
5 mM 0.57 mL 2.83 mL 5.67 mL
10 mM 0.28 mL 1.42 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735 PMID: 15867369

Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475 PMID: 15974942

Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313 PMID: 9789085


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Keywords: SC 560, supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, SC560, Cyclooxygenase, Tocris Bioscience

Citations for SC 560

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