Celecoxib

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Cat.No. 3786 - Celecoxib | C17H14F3N3O2S | CAS No. 169590-42-5
Description: Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: SC 58635, Celebrex
Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Anti-inflammatory with shorter plasma half-life in vivo than SC 58121 (Cat. No. 2895). Displays chemopreventive activity in in vivo tumor models.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Celecoxib is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 381.37
Formula C17H14F3N3O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 169590-42-5
PubChem ID 2662
InChI Key RZEKVGVHFLEQIL-UHFFFAOYSA-N
Smiles CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.53 25
ethanol 19.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 381.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.24 mL 26.22 mL 52.44 mL
2.5 mM 1.05 mL 5.24 mL 10.49 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
25 mM 0.1 mL 0.52 mL 1.05 mL

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References

References are publications that support the biological activity of the product.

Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 40 1347 PMID: 9135032

DeWitt (1999) Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 55 625 PMID: 10101019

Harris et al (2000) Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 60 2101 PMID: 10786667


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Keywords: Celecoxib, Celecoxib supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58635, Pfizer, SC, 58635, Celebrex, Cyclooxygenase, 3786, Tocris Bioscience

Citations for Celecoxib

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