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Description: Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: SC 58635,Celebrex
Chemical Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Purity: ≥99% (HPLC)
Citations (4)
Literature (2)

Biological Activity for Celecoxib

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively). Celecoxib is an anti-inflammatory with shorter plasma half-life in vivo than SC 58121. Displays chemopreventive activity in in vivo tumor models.

Compound Libraries for Celecoxib

Celecoxib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Celecoxib

M. Wt 381.37
Formula C17H14F3N3O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 169590-42-5
PubChem ID 2662
Smiles CC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Celecoxib

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 9.53 25
ethanol 19.07 50

Preparing Stock Solutions for Celecoxib

The following data is based on the product molecular weight 381.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.24 mL 26.22 mL 52.44 mL
2.5 mM 1.05 mL 5.24 mL 10.49 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
25 mM 0.1 mL 0.52 mL 1.05 mL

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Product Datasheets for Celecoxib

Certificate of Analysis / Product Datasheet
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References for Celecoxib

References are publications that support the biological activity of the product.

Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib). J.Med.Chem. 40 1347 PMID: 9135032

DeWitt (1999) Cox-2-selective Inhibitors: the new super aspirins. Mol.Pharmacol. 55 625 PMID: 10101019

Harris et al (2000) Chemoprevention of breast cancer in rats by celecoxib, a cyclooxygenase 2 inhibitor. Cancer Res. 60 2101 PMID: 10786667

If you know of a relevant reference for Celecoxib, please let us know.

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Keywords: Celecoxib, Celecoxib supplier, Selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Oxygenases, Oxidases, SC58635, prostaglandins, SC, 58635, Celebrex, Cyclooxygenase, 3786, Tocris Bioscience

4 Citations for Celecoxib

Citations are publications that use Tocris products. Selected citations for Celecoxib include:

Cesare et al (2020) Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. Front Cell Dev Biol 8 561179 PMID: 33134292

Bowler et al (2019) CXB Is Associated With Dystrophic Calcification and Aortic Valve Stenosis. JACC Basic Transl Sci 4 135 PMID: 31061914

Oguh-Olayinka et al (2019) The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res PMID: 30941737

Christopher J et al (2022) Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res 82 3375-3393 PMID: 35819261

Do you know of a great paper that uses Celecoxib from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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