SC 236

Pricing Availability   Qty
Description: Selective cyclooxygenase-2 (COX-2) inhibitor
Alternative Names: SC 58236
Chemical Name: 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for SC 236

SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for SC 236

SC 236 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SC 236

M. Wt 401.79
Formula C16H11ClF3N3O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 170569-86-5
PubChem ID 9865808
InChI Key NSQNZEUFHPTJME-UHFFFAOYSA-N
Smiles ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC 236

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.18 100
ethanol 40.18 100

Preparing Stock Solutions for SC 236

The following data is based on the product molecular weight 401.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for SC 236

References are publications that support the biological activity of the product.

Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810 PMID: 8663121

Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359 PMID: 15213717

Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347 PMID: 9135032


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Keywords: SC 236, SC 236 supplier, SC236, SC58236, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Pfizer, SC, 58236, Cyclooxygenase, 3919, Tocris Bioscience

Citations for SC 236

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Reviews for SC 236

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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