Acetaminophen

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Cat.No. 1706 - Acetaminophen | C8H9NO2 | CAS No. 103-90-2
Description: Cyclooxygenase inhibitor; may be selective for COX-3
Alternative Names: Paracetamol
Chemical Name: N-(4-Hydroxyphenyl)acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.

Compound Libraries

Acetaminophen is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 151.16
Formula C8H9NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 103-90-2
PubChem ID 1983
InChI Key RZVAJINKPMORJF-UHFFFAOYSA-N
Smiles CC(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 15.12 100
DMSO 15.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 151.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.62 mL 33.08 mL 66.16 mL
5 mM 1.32 mL 6.62 mL 13.23 mL
10 mM 0.66 mL 3.31 mL 6.62 mL
50 mM 0.13 mL 0.66 mL 1.32 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Chandrasekharan et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 99 13926 PMID: 12242329

Chong et al (2001) Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 35 1476 PMID: 11724102

Riendeau et al (1997) Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 75 1088 PMID: 9365818


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Keywords: Acetaminophen, Acetaminophen supplier, Cyclooxygenase, inhibitors, inhibits, COX-3, Oxygenases, Oxidases, Paracetamol, 1706, Tocris Bioscience

3 Citations for Acetaminophen

Citations are publications that use Tocris products. Selected citations for Acetaminophen include:

Inagaki et al (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci 13 13 PMID: 23137391

Liu and Gao (2007) Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol 97 837 PMID: 17093123

Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 104 4083 PMID: 17360481


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Literature in this Area

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