Cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||7.56||50mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 151.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.62 mL||33.08 mL||66.16 mL|
|5 mM||1.32 mL||6.62 mL||13.23 mL|
|10 mM||0.66 mL||3.31 mL||6.62 mL|
|50 mM||0.13 mL||0.66 mL||1.32 mL|
References are publications that support the products' biological activity.
Chandrasekharan et al (2002) COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc.Natl.Acad.Sci.U.S.A. 99 13926 PMID: 12242329
Chong et al (2001) Effect of acetaminophen on atherosclerosis. Ann.Pharmacother. 35 1476 PMID: 11724102
Riendeau et al (1997) Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. Can.J.Physiol.Pharmacol. 75 1088 PMID: 9365818
If you know of a relevant reference for Acetaminophen, please let us know.
View Related Products by Product Action
Keywords: Acetaminophen, supplier, Cyclooxygenase, inhibitors, inhibits, COX-3, Oxygenases, Oxidases, Paracetamol, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience
2 Citations for Acetaminophen
Citations are publications that use Tocris products. Selected citations for Acetaminophen include:
Inagaki et al (2012) Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph. J Neurosci 13 13 PMID: 23137391
Factor et al (2007) Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A 104 4083 PMID: 17360481
Do you know of a great paper that uses Acetaminophen from Tocris? If so please let us know.
Reviews for Acetaminophen
There are currently no reviews for this product. Be the first to review Acetaminophen and earn rewards!
Have you used Acetaminophen?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.