Indomethacin

Pricing Availability Delivery Time Qty
Cat.No. 1708 - Indomethacin | C19H16ClNO4 | CAS No. 53-86-1
Description: Cyclooxygenase inhibitor (COX-1 > COX-2)
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.

Technical Data

M. Wt 357.79
Formula C19H16ClNO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 53-86-1
PubChem ID 3715
InChI Key CGIGDMFJXJATDK-UHFFFAOYSA-N
Smiles COC1=CC=C2N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C(CC(O)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.78 100
ethanol 17.89 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 357.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.97 mL 27.95 mL
5 mM 0.56 mL 2.79 mL 5.59 mL
10 mM 0.28 mL 1.4 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402 PMID: 11906281

Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90 PMID: 343530

Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641 PMID: 5849618


If you know of a relevant reference for Indomethacin, please let us know.

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Keywords: Indomethacin, supplier, Cyclooxygenase, inhibitors, inhibits, COX-1, COX-2, Oxygenases, Oxidases, Cyclooxygenase, Tocris Bioscience

5 Citations for Indomethacin

Citations are publications that use Tocris products. Selected citations for Indomethacin include:

Miller et al (2012) CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A 109 20602 PMID: 23185004

Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902

Gonnermann et al (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. Oncoimmunology 4 e988460 PMID: 25949900

Cramer et al (2015) Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse. J Biomed Sci 35 5664 PMID: 25855180

Tang et al (2014) Lactate-mediated glia-neuronal signalling in the mammalian brain. Nat Commun 5 3284 PMID: 24518663


Do you know of a great paper that uses Indomethacin from Tocris? If so please let us know.

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