AM 6545

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Description: High affinity and selective CB1 antagonist
Chemical Name: 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Citations (1)
Literature (2)

Biological Activity for AM 6545

AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits >100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

Compound Libraries for AM 6545

AM 6545 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 6545

M. Wt 556.46
Formula C26H23Cl2N5O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1245626-05-4
PubChem ID 46912919
Smiles O=C(NN3CCS(CC3)(=O)=O)C1=NN(C2=CC=C(Cl)C=C2Cl)C(C4=CC=C(C#CCCC#N)C=C4)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AM 6545

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.13 20

Preparing Stock Solutions for AM 6545

The following data is based on the product molecular weight 556.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.99 mL 44.93 mL 89.85 mL
1 mM 1.8 mL 8.99 mL 17.97 mL
2 mM 0.9 mL 4.49 mL 8.99 mL
10 mM 0.18 mL 0.9 mL 1.8 mL

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Product Datasheets for AM 6545

Certificate of Analysis / Product Datasheet
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References for AM 6545

References are publications that support the biological activity of the product.

Tam et al (2010) Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J.Clin.Invest. 120 2953 PMID: 20664173

Bowles et al (2015) A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc.Natl.Acad.Sci.U.S.A. 112 285 PMID: 25535367

If you know of a relevant reference for AM 6545, please let us know.

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Keywords: AM 6545, AM 6545 supplier, AM6545, CB1, receptors, antagonists, high, affinity, selective, obesity, lipids, glucose, Receptors, 5443, Tocris Bioscience

1 Citation for AM 6545

Citations are publications that use Tocris products. Selected citations for AM 6545 include:

Giulio G et al (2022) Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Mol Psychiatry 27 2340-2354 PMID: 35075269

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.