High affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 380.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||13.14 mL||65.68 mL||131.35 mL|
|1 mM||2.63 mL||13.14 mL||26.27 mL|
|2 mM||1.31 mL||6.57 mL||13.14 mL|
|10 mM||0.26 mL||1.31 mL||2.63 mL|
References are publications that support the biological activity of the product.
Sink et al (2008) The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33 946 PMID: 17581535
Hodge et al (2008) The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 193 298 PMID: 18602425
If you know of a relevant reference for AM 4113, please let us know.
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Keywords: AM 4113, AM 4113 supplier, AM4113, high, affinity, selective, CB1, antagonists, Cannabinoids, Receptors, cb1r, 6193, Tocris Bioscience
Citations for AM 4113
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.