AM 4113

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Cat.No. 6193 - AM 4113 | C17H12Cl3N3O | CAS No. 614726-85-1
Description: High affinity and selective CB1 antagonist
Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity and selective CB1 antagonist (Kd = 0.89 nM). Exhibits 100-fold selectivity for CB1 over CB2. Attenuates CB1 agonist AM 411-induced locomotor suppression and reduces food intake in vivo, but does not induce signs of nausea.

Technical Data

M. Wt 380.66
Formula C17H12Cl3N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 614726-85-1
PubChem ID 66844170
InChI Key BBUKVPCUOHFAQN-UHFFFAOYSA-N
Smiles CC1=C(C2=CC=C(C=C2)Cl)N(C3=C(C=C(C=C3)Cl)Cl)N=C1C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.61 20
DMSO 7.61 20

Preparing Stock Solutions

The following data is based on the product molecular weight 380.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.14 mL 65.68 mL 131.35 mL
1 mM 2.63 mL 13.14 mL 26.27 mL
2 mM 1.31 mL 6.57 mL 13.14 mL
10 mM 0.26 mL 1.31 mL 2.63 mL

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References

References are publications that support the biological activity of the product.

Sink et al (2008) The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats. Neuropsychopharmacology 33 946 PMID: 17581535

Hodge et al (2008) The cannabinoid CB1 receptor inverse agonist AM 251 and antagonist AM 4113 produce similar effects on the behavioral satiety sequence in rats Behav. Brain Res. 193 298 PMID: 18602425


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Citations for AM 4113

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