PSNCBAM-1

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Cat.No. 5321 - PSNCBAM-1 | C22H21ClN4O | CAS No. 877202-74-9
Description: Negative allosteric modulator of CB1 receptors
Chemical Name: N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]urea
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.

Compound Libraries

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Technical Data

M. Wt 392.88
Formula C22H21ClN4O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 877202-74-9
PubChem ID 11560249
InChI Key HDAYFSFWIPRJSO-UHFFFAOYSA-N
Smiles ClC1=CC=C(NC(NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.29 100

Preparing Stock Solutions

The following data is based on the product molecular weight 392.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.73 mL 25.45 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID: 17592509

German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID: 25162172


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Keywords: PSNCBAM-1, PSNCBAM-1 supplier, subtype, selective, cb1, cannabinoids, receptors, negative, allosteric, modulators, antagonists, hypophagic, CB1, Receptors, 5321, Tocris Bioscience

Citations for PSNCBAM-1

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