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NESS 0327 New
Ultra-high affinity and selective CB1 receptor antagonist (Ki = 350 fM). Exhibits >60-fold selectivity for CB1 over CB2 receptors. Antagonizes the inhibitory effects of WIN 55,212-2 (Cat. No. 1038) on electrically evoked contractions in mouse isolated vas deferens ex vivo. Also antagonizes the antinociceptive effect of WIN 55,212-2 in tail-flick and hot plate tests in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 489.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||10.21 mL||51.04 mL||102.08 mL|
|1 mM||2.04 mL||10.21 mL||20.42 mL|
|2 mM||1.02 mL||5.1 mL||10.21 mL|
|10 mM||0.2 mL||1.02 mL||2.04 mL|
References are publications that support the biological activity of the product.
Ruiu et al (2003) Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor. J.Pharmacol.Exp.Ther. 306 363 PMID: 12663689
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Keywords: NESS 0327, NESS 0327 supplier, NESS0327, cannabinoid, receptors, CB1, antagonists, antagonism, ultra, high, affinity, selective, Receptors, 5746, Tocris Bioscience
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Literature in this Area
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.