CP 945598 hydrochloride

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Description: CB1 antagonist
Chemical Name: 1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)piperidine-4-carboxamide hydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for CP 945598 hydrochloride

CP 945598 hydrochloride is a selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for CP 945598 hydrochloride

M. Wt 546.88
Formula C25H25Cl2N7O.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 686347-12-6
PubChem ID 16223963
Smiles CCNC(CC4)(C(N)=O)CCN4C1=NC=NC2=C1N=C(C5=C(Cl)C=CC=C5)N2C3=CC=C(Cl)C=C3.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CP 945598 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 10.94 20

Preparing Stock Solutions for CP 945598 hydrochloride

The following data is based on the product molecular weight 546.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.14 mL 45.71 mL 91.43 mL
1 mM 1.83 mL 9.14 mL 18.29 mL
2 mM 0.91 mL 4.57 mL 9.14 mL
10 mM 0.18 mL 0.91 mL 1.83 mL

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Product Datasheets for CP 945598 hydrochloride

References for CP 945598 hydrochloride

References are publications that support the biological activity of the product.

Griffith et al (2009) Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist. J.Med.Chem. 52 234 PMID: 19102698

Hadcock et al (2010) In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB1 receptor antagonist for the management of obesity. Biochem.Biophys.Res.Commun. 394 366 PMID: 20211605

If you know of a relevant reference for CP 945598 hydrochloride, please let us know.

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1 Citation for CP 945598 hydrochloride

Citations are publications that use Tocris products. Selected citations for CP 945598 hydrochloride include:

Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731

Do you know of a great paper that uses CP 945598 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.