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Biological Activity for Tocrifluor T1117
Tocrifluor T1117 is a fluorescent form of AM 251. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
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Optical Data for Tocrifluor T1117
|Application||Fluorescence Microscopy, Confocal Microscopy|
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Technical Data for Tocrifluor T1117
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Tocrifluor T1117
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Tocrifluor T1117
The following data is based on the product molecular weight 974.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||10.26 mL||51.28 mL||102.57 mL|
|0.5 mM||2.05 mL||10.26 mL||20.51 mL|
|1 mM||1.03 mL||5.13 mL||10.26 mL|
|5 mM||0.21 mL||1.03 mL||2.05 mL|
Product Datasheets for Tocrifluor T1117
References for Tocrifluor T1117
References are publications that support the biological activity of the product.
Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br.J.Pharmacol. 159 787 PMID: 20136833
Daly et al (2008) Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors. Vascular and Smooth Muscle Phys.Soc. Symposium
Sylantyev et al (2013) Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. Proc.Natl.Acad.Sci.U.S.A. 110 5193 PMID: 23472002
Bruno et al (2014) Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay. Sci.Rep. 4 3757 PMID: 24441508
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Keywords: Tocrifluor T1117, Tocrifluor T1117 supplier, fluorescent, CB1, receptor, ligands, Fluorescent, Probes, cannabinoids, Receptors, cb1r, cb2r, TR-FRET, F, Receptor, GPR55, and, FP, Assay, Reagents, 2540, Tocris Bioscience
3 Citations for Tocrifluor T1117
Citations are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:
Stornaiuolo et al (2015) Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments. Sci Rep 5 15453 PMID: 26482099
Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol 159 787 PMID: 20136833
Tortoriello et al (2013) Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides. PLoS One 8 e67865 PMID: 23874457
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Literature in this Area
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Fluorescent Dyes and Probes Research Product Guide
This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:
- Fluorescent Dyes, including dyes for flow cytometry
- Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
- Tissue Clearing Kits and Reagents
- Aptamer-based RNA Imaging Reagents
- Fluorescent Probes for Imaging Bacteria
- TSA VividTM Fluorophore Kits
- TSA Reagents for Enhancing IHC, ICC & FISH Signals