Tocrifluor T1117

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Cat.No. 2540 - Tocrifluor T1117 | C56H53Cl2N7O5 | CAS No. 1186195-59-4
Description: Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117)
Chemical Name: N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Fluorescent form of AM 251 (Cat. No. 1117). AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity.

Technical Data

M. Wt 974.97
Formula C56H53Cl2N7O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1186195-59-4
PubChem ID 57369426
InChI Key RNAPRXIZPJDYPH-UHFFFAOYSA-N
Smiles CN(C)C1=CC2=C(C=C1)C1(OC(=O)C3=C1C=CC(=C3)C(=O)NCCCC1=CC=C(C=C1)C1=CC=C(C=C1)C1=C(C)C(=NN1C1=CC=C(Cl)C=C1Cl)C(=O)NN1CCCCC1)C1=C(O2)C=C(C=C1)N(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.75 10

Preparing Stock Solutions

The following data is based on the product molecular weight 974.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.03 mL 5.13 mL 10.26 mL
5 mM 0.21 mL 1.03 mL 2.05 mL
10 mM 0.1 mL 0.51 mL 1.03 mL
50 mM 0.02 mL 0.1 mL 0.21 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br.J.Pharmacol. 159 787 PMID: 20136833

Daly et al (2008) Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors. Vascular and Smooth Muscle Phys.Soc. Symposium PMID:

Sylantyev et al (2013) Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. Proc.Natl.Acad.Sci.U.S.A. 110 5193 PMID: 23472002

Bruno et al (2014) Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay. Sci.Rep. 4 3757 PMID: 24441508


If you know of a relevant reference for Tocrifluor T1117, please let us know.

Keywords: fluorescent CB1 receptor ligands Fluorescent Probes cannabinoids Receptors cb1r cb2r CB1 Receptors

2 Citations for Tocrifluor T1117

Citations are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:

Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol 159 787 PMID: 20136833

Tortoriello et al (2013) Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides. PLoS One 8 e67865 PMID: 23874457


Do you know of a great paper that uses Tocrifluor T1117 from Tocris? If so please let us know.

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