Hemopressin (human, mouse)

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Cat.No. 3791 - Hemopressin (human, mouse) | Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His | CAS No. 1314035-51-2
Description: Selective CB1 inverse agonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.

Technical Data

M. Wt 1054.26
Formula C50H79N13O12
Sequence PVNFKLLSH
Storage Store at -20°C
CAS Number 1314035-51-2
PubChem ID 90488877
InChI Key JEXQOFXDPAGOQL-TZFLQVIRSA-N
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972

Blais et al (2005) Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 26 1317 PMID: 16042973

Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA 104 20588


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Keywords: Hemopressin (human, mouse), Hemopressin (human, mouse) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Receptors, Other, /, Activators, 3791, Tocris Bioscience

Citations for Hemopressin (human, mouse)

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