Hemopressin (human, mouse)

Pricing Availability   Qty
Description: Selective CB1 inverse agonist
Citations (1)
Reviews (1)
Literature (2)

Biological Activity for Hemopressin (human, mouse)

Hemopressin (human, mouse) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity in vivo.

Technical Data for Hemopressin (human, mouse)

M. Wt 1054.26
Formula C50H79N13O12
Storage Store at -20°C
CAS Number 1314035-51-2
PubChem ID 90488877
Smiles [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Hemopressin (human, mouse)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Hemopressin (human, mouse)

Certificate of Analysis / Product Datasheet
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References for Hemopressin (human, mouse)

References are publications that support the biological activity of the product.

Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972

Blais et al (2005) Hypotensive effects of hemopressin and bradykinin in rabbits, rats and mice. A comparative study. Peptides 26 1317 PMID: 16042973

Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.USA 104 20588

If you know of a relevant reference for Hemopressin (human, mouse), please let us know.

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Keywords: Hemopressin (human, mouse), Hemopressin (human, mouse) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, Receptors, Other, /, Activators, 3791, Tocris Bioscience

1 Citation for Hemopressin (human, mouse)

Citations are publications that use Tocris products. Selected citations for Hemopressin (human, mouse) include:

Jimenez-Blasco et al (2020) Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature 583 603 PMID: 32641832

Do you know of a great paper that uses Hemopressin (human, mouse) from Tocris? Please let us know.

Reviews for Hemopressin (human, mouse)

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Our experiments looked into CB1 receptors using Hemopressin.
By Anonymous on 02/19/2019
Species: Human

The endocannabinoid system consists of at least two cannabinoid receptors, CB1 and CB2. Our experiments looked into CB1 receptors using Hemopressin and they were cloned.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

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