TM 38837

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Cat.No. 7131 - TM 38837 | C30H25Cl2F3N4OS | CAS No. 1253641-65-4
Description: Highly potent CB1 inverse agonist; peripherally restricted
Chemical Name: 1-(2,4-Dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (6)

Biological Activity

Highly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8.5 nM and 605 nM for inhibition of [3H]-CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71-fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1-overexpressing cell membranes in vitro (EC50 = 18.5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice.

Technical Data

M. Wt 617.51
Formula C30H25Cl2F3N4OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1253641-65-4
PubChem ID 49779607
InChI Key VQOCBFYUDSBDCZ-UHFFFAOYSA-N
Smiles CCC1=C(C2=CC=C(C#CC3=CC=C(C(F)(F)F)C=C3)S2)N(C4=C(C=C(C=C4)Cl)Cl)N=C1C(NN5CCCCC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.35 20
ethanol 12.35 20

Preparing Stock Solutions

The following data is based on the product molecular weight 617.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.1 mL 40.49 mL 80.97 mL
1 mM 1.62 mL 8.1 mL 16.19 mL
2 mM 0.81 mL 4.05 mL 8.1 mL
10 mM 0.16 mL 0.81 mL 1.62 mL

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Keywords: TM 38837, TM 38837 supplier, TM38837, cannabinoid, CB1, receptor, inverse, agonist, highly, potent, peripherally, restricted, Receptors, 7131, Tocris Bioscience

Citations for TM 38837

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