TM 38837

Pricing Availability   Qty
Description: Highly potent CB1 inverse agonist; peripherally restricted
Chemical Name: 1-(2,4-Dichlorophenyl)-4-ethyl-N-1-piperidinyl-5-[5-[2-[4-(trifluoromethyl)phenyl]ethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for TM 38837

TM 38837 is a highly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8.5 nM and 605 nM for inhibition of [3H]-CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71-fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1-overexpressing cell membranes in vitro (EC50 = 18.5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice.

Compound Libraries for TM 38837

TM 38837 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TM 38837

M. Wt 617.51
Formula C30H25Cl2F3N4OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1253641-65-4
PubChem ID 49779607
InChI Key VQOCBFYUDSBDCZ-UHFFFAOYSA-N
Smiles CCC1=C(C2=CC=C(C#CC3=CC=C(C(F)(F)F)C=C3)S2)N(C4=C(C=C(C=C4)Cl)Cl)N=C1C(NN5CCCCC5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TM 38837

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.35 20
ethanol 12.35 20

Preparing Stock Solutions for TM 38837

The following data is based on the product molecular weight 617.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.1 mL 40.49 mL 80.97 mL
1 mM 1.62 mL 8.1 mL 16.19 mL
2 mM 0.81 mL 4.05 mL 8.1 mL
10 mM 0.16 mL 0.81 mL 1.62 mL

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Keywords: TM 38837, TM 38837 supplier, TM38837, cannabinoid, CB1, receptor, inverse, agonist, highly, potent, peripherally, restricted, Receptors, 7131, Tocris Bioscience

Citations for TM 38837

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Reviews for TM 38837

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cannabinoid Receptor Ligands Scientific Review

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.