Angiotensin-Converting Enzyme

Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate the vasodilator, proinflammatory peptide, bradykinin.

Products
Background
Literature (1)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
2578 Benazepril hydrochloride
Angiotensin-converting enzyme (ACE) inhibitor
4455 Captopril
ACE inhibitor; also inhibits LTA4 hydrolase
4302 Perindopril erbumine
Angiotensin-converting enzyme (ACE) inhibitor
5250 Ramipril
Non-peptide, competitive angiotensin-converting enzyme (ACE) inhibitor
2931 Spinorphin
Enkephalin-degrading and ACE inhibitor

Substrates

Cat. No. Product Name / Activity
1563 Angiotensin I (human, mouse, rat)
Endogenous peptide substrate of ACE
3791 Hemopressin (human, mouse)
Bioactive substrate for endopeptidase 24.15, neurolysin and ACE
1764 Hemopressin (rat)
Bioactive substrate for endopeptidase 24.15, neurolysin and ACE

Ligands

Cat. No. Product Name / Activity
6006 Acein
High affinity angiotensin-converting enzyme (ACE) ligand

Other

Cat. No. Product Name / Activity
5491 Aliskiren hemifumarate
Potent renin inhibitor; antihypertensive

Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate the vasodilator peptide, bradykinin.

There are two isoforms of ACE, a smaller/single catalytic site enzyme found in the testes and a more widely expressed ~180kDa dual active site isoform. ACE is often membrane bound. In contrast to ACE, the homolog ACE2, has recently been shown to cleave and inactivate angiotensin II to generate the vasodilator Angiotensin (1-7). ACE inhibitors are widely used to treat hypertension and cardiovascular diseases. ACE inhibitors have also been used to slow nephropathy, particularly when it is associated with diabetes.

External sources of pharmacological information for Angiotensin-Converting Enzyme :

    Literature for Angiotensin-Converting Enzyme

    Tocris offers the following scientific literature for Angiotensin-Converting Enzyme to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cardiovascular

    Cardiovascular Research Product Guide

    A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

    • Hypertension
    • Thrombosis and Hemostasis
    • Atherosclerosis
    • Myocardial Infarction
    • Ischemia/Reperfusion Injury
    • Arrhythmias
    • Heart Failure

    Angiotensin-Converting Enzyme Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Angiotensin-converting enzyme I Human ACE NM_152830 P22966
    Mouse Ace NM_207624 P09470
    Rat Ace NM_012544 Q8CFN1
    Angiotensin-converting enzyme 2 Human ACE2 NM_021804 Q9BYF1
    Mouse Ace2 NM_027286 Q8R0I0
    Rat Ace2 NM_001012006 Q5EGZ1
    Angiotensin-converting enzyme 3 Mouse Ace3 NM_001101453 NP_001094923