Potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 609.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.64 mL||8.2 mL||16.4 mL|
|5 mM||0.33 mL||1.64 mL||3.28 mL|
|10 mM||0.16 mL||0.82 mL||1.64 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
References are publications that support the products' biological activity.
Jensen et al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399 PMID: 18340340
Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127 PMID: 17268484
If you know of a relevant reference for Aliskiren hemifumarate, please let us know.
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Keywords: Aliskiren hemifumarate, supplier, SPP100, Potent, renin, inhibitors, inhibits, hypertensive, hypertension, blood, pressure, heart, SPP, 100, Other, Proteases, Angiotensin-Converting, Enzyme, Other, Proteases, Tocris Bioscience
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