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Biological Activity for Aliskiren hemifumarate
Aliskiren hemifumarate is a potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
Compound Libraries for Aliskiren hemifumarate
Technical Data for Aliskiren hemifumarate
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Aliskiren hemifumarate
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Aliskiren hemifumarate
The following data is based on the product molecular weight 609.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.64 mL||8.2 mL||16.4 mL|
|5 mM||0.33 mL||1.64 mL||3.28 mL|
|10 mM||0.16 mL||0.82 mL||1.64 mL|
|50 mM||0.03 mL||0.16 mL||0.33 mL|
Product Datasheets for Aliskiren hemifumarate
References for Aliskiren hemifumarate
References are publications that support the biological activity of the product.
Jensen et al (2) Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 7 399 PMID: 18340340
Kaye and Krum (2007) Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 6 127 PMID: 17268484
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Citations for Aliskiren hemifumarate
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Currently there are no citations for Aliskiren hemifumarate. Do you know of a great paper that uses Aliskiren hemifumarate from Tocris? Please let us know.
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