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Submit ReviewBradykinin
Description: Endogenous agonist at bradykinin receptors (B2 > B1)
Purity: ≥95% (HPLC)
Biological Activity for Bradykinin
Bradykinin is an endogenous bradykinin receptor agonist that displays selectivity for B2 over B1 receptors. Proinflammatory peptide.
Technical Data for Bradykinin
| M. Wt | 1060.22 |
| Formula | C50H73N15O11 |
| Sequence | RPPGFSPFR |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 58-82-2 |
| PubChem ID | 439201 |
| InChI Key | QXZGBUJJYSLZLT-FDISYFBBSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Bradykinin
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Bradykinin
References for Bradykinin
References are publications that support the biological activity of the product.
Regoli et al (1998) Bradykinin receptors and their antagonists. Eur.J.Pharmacol. 348 1 PMID: 9650825
Leeb-Lundberg et al (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
Abraham et al (2006) Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease Eur.J.Pharmacol. 533 215 PMID: 16455073
If you know of a relevant reference for Bradykinin, please let us know.
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Keywords: Bradykinin, Bradykinin supplier, Endogenous, agonists, bradykinin, receptors, B2, B1, Receptors, Bradykinin, 3004, Tocris Bioscience
7 Citations for Bradykinin
Citations are publications that use Tocris products. Selected citations for Bradykinin include:
Zhang (2019) Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation. Cell Rep 27 3672 PMID: 31216483
Jakubowska et al (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol. 6 160149 PMID: 27488376
Kirkby et al (2012) Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Gastroenterology 109 17597 PMID: 23045674
Zakaria et al (2014) Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms. BMC Complement Altern Med 14 63 PMID: 24555641
Bell et al (2014) Retinal vasculature of adult zebrafish: in vivo imaging using confocal scanning laser ophthalmoscopy. Exp Eye Res 129 107 PMID: 25447564
Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Proc Natl Acad Sci U S A 288 27434 PMID: 23940034
Zhou et al (2019) Serum bradykinin levels as a diagnostic marker in cervical cancer with a potential mechanism to promote VEGF expression via BDKRB2. Int J Oncol 55 131 PMID: 31059006
Do you know of a great paper that uses Bradykinin from Tocris? Please let us know.
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