Bradykinin

Pricing Availability Delivery Time Qty
Cat.No. 3004 - Bradykinin | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | CAS No. 58-82-2
Description: Endogenous agonist at bradykinin receptors (B2 > B1)
Datasheet
Citations (5)
Literature

Biological Activity

Endogenous bradykinin receptor agonist that displays selectivity for B2 over B1 receptors. Proinflammatory peptide.

Technical Data

M. Wt 1060.22
Formula C50H73N15O11
Sequence RPPGFSPFR
Storage Desiccate at -20°C
CAS Number 58-82-2
PubChem ID 439201
InChI Key QXZGBUJJYSLZLT-FDISYFBBSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1060.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.94 mL 4.72 mL 9.43 mL
5 mM 0.19 mL 0.94 mL 1.89 mL
10 mM 0.09 mL 0.47 mL 0.94 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Regoli et al (1998) Bradykinin receptors and their antagonists. Eur.J.Pharmacol. 348 1 PMID: 9650825

Leeb-Lundberg et al (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727

Abraham et al (2006) Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease Eur.J.Pharmacol. 533 215 PMID: 16455073


If you know of a relevant reference for Bradykinin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Bradykinin Receptor Agonists

Keywords: Bradykinin, supplier, Endogenous, agonists, bradykinin, receptors, B2, B1, Receptors, Bradykinin, Receptors, Bradykinin, Receptors, Tocris Bioscience

5 Citations for Bradykinin

Citations are publications that use Tocris products. Selected citations for Bradykinin include:

Hannedouche et al (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. Proc Natl Acad Sci U S A 288 27434 PMID: 23940034

Kirkby et al (2012) Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Gastroenterology 109 17597 PMID: 23045674

Jakubowska et al (2016) Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biol. 6 160149 PMID: 27488376

Zakaria et al (2014) Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms. BMC Complement Altern Med 14 63 PMID: 24555641

Bell et al (2014) Retinal vasculature of adult zebrafish: in vivo imaging using confocal scanning laser ophthalmoscopy. Exp Eye Res 129 107 PMID: 25447564


Do you know of a great paper that uses Bradykinin from Tocris? If so please let us know.

Bradykinin Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used Bradykinin?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.