Angiotensin Receptors

The angiotensin family of peptides is important in the regulation of blood volume, vascular resistance and electrolyte balance. Angiotensin II, the main peptide of the renin-angiotensin system, produces a variety of physiological effects. It is produced in a cascade whereby the precursor peptide angiotensinogen is cleaved to produce renin and angiotensin I. Angiotensin-converting enzyme then acts on angiotensin I to yield the octapeptide angiotensin II, and further processing generates angiotensin III and IV. These peptides act on three angiotensin receptor subtypes, AT1, AT2 and AT4, the properties of which are summarized below. The actions of angiotensin II are primarily mediated by AT1, whereas AT2 preferentially binds angiotensin III and AT4 is selective for angiotensin IV.

Targets
Literature
Receptor Data

Literature for Angiotensin Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Angiotensin Receptor Data

Receptor Subtype AT1 Receptors AT2 Receptors AT4 Receptors
Transduction Mechanism Gq/11 Gi/o Unknown
Primary Locations Liver, kidney, adrenal gland, lung Brain, adrenal medulla, heart, uterus Kidney, brain, adrenal gland, heart, liver, lung
Tissue Functions Mediates vasoconstriction, regulates aldosterone and vasopressin release, salt and water retention, cell proliferation and migration, sympathetic stimulation Counterbalances effects of the AT1 receptor Regulates blood flow and renal tubular reabsorption, affects cardiac hypertrophy and memory acquisition
Selective Agonists - CGP 42112 (2569) -
Selective Antagonists ZD 7155 (1211)
EMD 66684 (1849)
PD 123319 (1361) -

References

Gasparo et al (2000) International Union of Pharmacology XXIII. The angiotensin II receptors. Pharmacol.Rev. 52 415. Alexander et al (2000) Guide to receptors and channels. Br.J.Pharmacol. 141 Suppl.1.