Angiotensin AT1 Receptors

The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.

Products
Background
Literature
Gene Data

Antagonists

Cat No Product Name / Activity
4553 Azilsartan
Potent AT1 receptor inverse agonist; antihypertensive
4791 Candesartan
AT1 receptor antagonist
4792 Candesartan cilexetil
Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist
1849 EMD 66684
Potent, selective non-peptide AT1 antagonist
5728 EXP 3174
Potent and selective AT1 receptor antagonist
5798 Irbesartan
Potent AT1 antagonist
3798 Losartan potassium
Selective, non-peptide AT1 antagonist
4616 Olmesartan
Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)
5139 Telmisartan
AT1 antagonist; PPARγ partial agonist
4216 Valsartan
High affinity, selective AT1 antagonist
1211 ZD 7155 hydrochloride
Selective non-peptide AT1 antagonist

The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.

Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).

External sources of pharmacological information for Angiotensin AT1 Receptors :

Literature for Angiotensin AT1 Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Angiotensin AT1 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AT1A Human AGTR1 NM_000685 P30556
Mouse Agtr1a NM_177322 P29754
Rat Agtr1a NM_030985 P25095
AT1B Mouse Agtr1b NM_175086 P29755
Rat Agtr1b NM_031009 P29089