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The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.
|Cat No||Product Name / Activity|
|Potent AT1 receptor inverse agonist; antihypertensive|
|AT1 receptor antagonist|
|Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist|
|Potent, selective non-peptide AT1 antagonist|
|Potent and selective AT1 receptor antagonist|
|Potent AT1 antagonist|
|Selective, non-peptide AT1 antagonist|
|Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)|
|AT1 antagonist; PPARγ partial agonist|
|High affinity, selective AT1 antagonist|
|1211||ZD 7155 hydrochloride|
|Selective non-peptide AT1 antagonist|
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.
Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).