Angiotensin AT1 Receptors
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.
Angiotensin AT1 Receptor Antagonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 4791 | Candesartan |
| AT1 antagonist | |
| 5728 | EXP 3174 |
| Potent and selective AT1 antagonist | |
| 5798 | Irbesartan |
| Potent AT1 antagonist | |
| 3798 | Losartan potassium |
| Selective, non-peptide AT1 antagonist | |
| 4616 | Olmesartan |
| Potent AT1 antagonist | |
| 4216 | Valsartan |
| High affinity, selective AT1 antagonist | |
| 1211 | ZD 7155 hydrochloride |
| Selective non-peptide AT1 antagonist | |
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.
Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).