The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.
Inverse Agonists |
Cat. No. | Product Name / Activity |
---|---|
4553 | Azilsartan |
Potent AT1 inverse agonist; antihypertensive | |
Antagonists |
Cat. No. | Product Name / Activity |
4791 | Candesartan |
AT1 antagonist | |
4792 | Candesartan cilexetil |
Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist | |
1849 | EMD 66684 |
Potent and selective non-peptide AT1 antagonist | |
5728 | EXP 3174 |
Potent and selective AT1 antagonist | |
5798 | Irbesartan |
Potent AT1 antagonist | |
3798 | Losartan potassium |
Selective, non-peptide AT1 antagonist | |
4616 | Olmesartan |
Potent AT1 antagonist | |
5139 | Telmisartan |
AT1 antagonist; PPARγ partial agonist | |
4216 | Valsartan |
High affinity, selective AT1 antagonist | |
1211 | ZD 7155 hydrochloride |
Selective non-peptide AT1 antagonist |
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.
Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).
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