Angiotensin AT1 Receptors
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung. AT1 receptors preferentially bind angiotensin II.
Antagonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 4553 | Azilsartan |
| Potent AT1 receptor inverse agonist; antihypertensive | |
| 4791 | Candesartan |
| AT1 receptor antagonist | |
| 4792 | Candesartan cilexetil |
| Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist | |
| 1849 | EMD 66684 |
| Potent, selective non-peptide AT1 antagonist | |
| 4696 | Eprosartan mesylate |
| Potent and selective AT1 receptor antagonist | |
| 5728 | EXP 3174 |
| Potent and selective AT1 receptor antagonist | |
| 5798 | Irbesartan |
| Potent AT1 antagonist | |
| 3798 | Losartan potassium |
| Selective, non-peptide AT1 antagonist | |
| 4616 | Olmesartan |
| Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620) | |
| 4620 | Olmesartan medoxomil |
| Selective non-peptide AT1 antagonist; prodrug of Olmesartan | |
| 5139 | Telmisartan |
| AT1 antagonist; PPARγ partial agonist | |
| 4216 | Valsartan |
| High affinity, selective AT1 antagonist | |
| 1211 | ZD 7155 hydrochloride |
| Selective non-peptide AT1 antagonist | |
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.
Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).
External sources of pharmacological information for Angiotensin AT1 Receptors :
Literature for Angiotensin AT1 Receptors
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Cardiovascular Poster
Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.
Our Cardiovascular Guide highlights over 250 products for cardiovascular research.
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Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors.
Request copyDownload PDFWritten by J.J. Maguire and A.P. Davenport
Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity.
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