Angiotensin II

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Cat.No. 1158 - Angiotensin II | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | CAS No. 4474-91-3
Description: Potent vasoconstrictor peptide
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone.

Technical Data

M. Wt 1046.2
Formula C50H71N13O12
Sequence DRVYIHPF
Storage Desiccate at -20°C
CAS Number 4474-91-3
PubChem ID 172198
InChI Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1046.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.78 mL 9.56 mL
5 mM 0.19 mL 0.96 mL 1.91 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Clayton et al (1998) Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetised rat. Br.J.Pharmacol. 124 1467 PMID: 9723960

Mosequeda-Garcia et al (1990) Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. J.Pharmacol.Exp.Ther. 255 374 PMID: 2213569

Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90 581 PMID: 10215161


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5 Citations for Angiotensin II

Citations are publications that use Tocris products. Selected citations for Angiotensin II include:

Nistala et al (2010) Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. J Mol Endocrinol 19 4790 PMID: 20871099

Vinciguerra et al (2009) Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) 2 43 PMID: 20228935

Rodrigues-Diez et al (2015) The C-terminal module IV of connective tissue growth factor, through EGFR/Nox1 signaling, activates the NF-κB pathway and proinflammatory factors in vascular smooth muscle cells. Hum Mol Genet 22 29 PMID: 25065408

Felizola et al (2014) PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues. Proc Natl Acad Sci U S A 52 159 PMID: 24403568

Klingerman et al (2016) Acute Metabolic Effects of Olanzapine Depend on Dose and Injection Site. Dose Response 13 1559325815618910 PMID: 26740814


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