Angiotensin II

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Cat.No. 1158 - Angiotensin II | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | CAS No. 4474-91-3
Description: Potent vasoconstrictor peptide
Datasheet
Citations (10)
Reviews (1)
Literature (4)

Biological Activity

Endogenous potent vasoconstrictor peptide; endogenous substrate for ACE2. Stimulates the synthesis and release of aldosterone.

Technical Data

M. Wt 1046.2
Formula C50H71N13O12
Sequence DRVYIHPF
Storage Desiccate at -20°C
CAS Number 4474-91-3
PubChem ID 172198
InChI Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Clayton et al (1998) Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetised rat. Br.J.Pharmacol. 124 1467 PMID: 9723960

Mosequeda-Garcia et al (1990) Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. J.Pharmacol.Exp.Ther. 255 374 PMID: 2213569

Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90 581 PMID: 10215161


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Keywords: Angiotensin II, Angiotensin II supplier, Potent, vasoconstrictor, peptide, AT, Receptors, Non-Selective, Angiotensin, AngiotensinII, Non-selective, ACE2, 1158, Tocris Bioscience

10 Citations for Angiotensin II

Citations are publications that use Tocris products. Selected citations for Angiotensin II include:

Nistala et al (2010) Differential effects of alendr. and los. therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. J Mol Endocrinol 19 4790 PMID: 20871099

Klingerman et al (2016) Acute Metabolic Effects of olanz. Depend on Dose and Injection Site. Dose Response 13 1559325815618910 PMID: 26740814

Vinciguerra et al (2009) Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. Aging (Albany NY) 2 43 PMID: 20228935

Bake et al (2018) Ghrelin's effects on food motivation in rats are not limited to palatable foods. J Neuroendocrinol e12665 PMID: 30525248


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Reviews for Angiotensin II

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Angiotensin II-induced H9c2 cell hypertrophy in vitro study.
By YANCHUN XU on 01/05/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: H9C2

We used this product to treat H9C2 cells to induce the cell hypetrophy and investigate the cell signalling pathway

PMID: 28550180 Reference
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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