Angiotensin (1-7)

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Cat.No. 1562 - Angiotensin (1-7) | Asp-Arg-Val-Tyr-Ile-His-Pro | CAS No. 51833-78-4
Description: Vasorelaxant peptide
Alternative Names: [Ile5]Angiotensin I (1-7), Ang-(1-7)
Datasheet
Citations
Literature

Biological Activity

Endogenous peptide fragment. Induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. Counteracts the vasoconstrictive and proliferative effects of angiotensin II and stimulates vasopressin (anti-diuretic hormone) release in vivo.

Technical Data

M. Wt 899
Formula C41H62N12O11
Sequence DRVYIHP
Storage Desiccate at -20°C
CAS Number 51833-78-4
PubChem ID 123805
InChI Key PVHLMTREZMEJCG-GDTLVBQBSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 899. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.11 mL 5.56 mL 11.12 mL
5 mM 0.22 mL 1.11 mL 2.22 mL
10 mM 0.11 mL 0.56 mL 1.11 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lemos et al (2002) Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mRen-2 transgenic rats. Br.J.Pharmacol. 135 1743 PMID: 11934815

Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45 PMID: 10967201

Santos et al (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc.Natl.Acad.Sci.U.S.A. 100 8258 PMID: 12829792


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Keywords: Angiotensin (1-7), supplier, Vasorelaxant, peptide, AT, Receptors, Non-Selective, Angiotensin, agonists, Mas, [Ile5]Angiotensin, I, (1-7), Ang-(1-7), Non-selective, AT, Receptors, Tocris Bioscience

Citations for Angiotensin (1-7)

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Literature in this Area

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Pathways for Angiotensin (1-7)

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