Angiotensin (1-7)

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Cat.No. 1562 - Angiotensin (1-7) | Asp-Arg-Val-Tyr-Ile-His-Pro | CAS No. 51833-78-4
Description: Vasorelaxant peptide
Alternative Names: [Ile5]Angiotensin I (1-7), Ang-(1-7)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Endogenous peptide fragment. Induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. Counteracts the vasoconstrictive and proliferative effects of angiotensin II and stimulates vasopressin (anti-diuretic hormone) release in vivo.

Technical Data

M. Wt 899
Formula C41H62N12O11
Sequence DRVYIHP
Storage Desiccate at -20°C
CAS Number 51833-78-4
PubChem ID 123805
InChI Key PVHLMTREZMEJCG-GDTLVBQBSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lemos et al (2002) Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mRen-2 transgenic rats. Br.J.Pharmacol. 135 1743 PMID: 11934815

Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45 PMID: 10967201

Santos et al (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc.Natl.Acad.Sci.U.S.A. 100 8258 PMID: 12829792


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Keywords: Angiotensin (1-7), Angiotensin (1-7) supplier, Vasorelaxant, peptide, AT, Receptors, Non-Selective, Angiotensin, agonists, Mas, [Ile5]Angiotensin, I, (1-7), Ang-(1-7), Non-selective, 1562, Tocris Bioscience

1 Citation for Angiotensin (1-7)

Citations are publications that use Tocris products. Selected citations for Angiotensin (1-7) include:

Pan et al (2018) FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice. Cell Metab 27 1323 PMID: 29706566


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Literature in this Area

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