5-HT6 Receptors
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and a role in spatial learning and memory.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 2382 | EMD 386088 hydrochloride |
| Potent 5-HT6 agonist | |
| 4209 | EMDT oxalate |
| Selective 5-HT6 agonist | |
| 4337 | ST 1936 oxalate |
| Selective, high affinity 5-HT6 agonist | |
| 5589 | WAY 181187 oxalate |
| High affinity and selective 5-HT6 agonist | |
| 3904 | WAY 208466 dihydrochloride |
| Selective 5-HT6 agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 3326 | BGC 20-761 |
| High affinity 5-HT6 antagonist | |
| 4208 | MS 245 oxalate |
| High affinity 5-HT6 antagonist | |
| 3285 | NPS ALX Compound 4a dihydrochloride |
| Potent and selective 5-HT6 antagonist | |
| 4964 | R 1485 dihydrochloride |
| Selective and high affinity 5-HT6 antagonist | |
| 2911 | Ro 04-6790 |
| Potent and selective 5-HT6 antagonist | |
| 1961 | SB 258585 hydrochloride |
| Potent, selective 5-HT6 antagonist | |
| 3368 | SB 271046 hydrochloride |
| Selective, orally active 5-HT6 antagonist | |
| 3189 | SB 399885 hydrochloride |
| Potent and selective 5-HT6 antagonist | |
| 3688 | SGS 518 oxalate |
| Selective 5-HT6 antagonist | |
Other |
|
| Cat No | Product Name / Activity |
| 0590 | Metergoline |
| Has moderate affinity for 5-HT6 and high affinity for 5-HT7. Also 5-HT1/5-HT2 antagonist | |
| 0558 | 2-Methyl-5-hydroxytryptamine hydrochloride |
| 5-HT3 agonist/potent 5-HT6 ligand | |
| 0997 | Mianserin hydrochloride |
| Has moderate affinity for 5-HT6. Also 5-HT2 antagonist | |
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has been localized to chromosome 1 (1p35-36).
External sources of pharmacological information for 5-HT6 Receptors :
Literature for 5-HT6 Receptors
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