5-HT6 Receptors
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and a role in spatial learning and memory.
Agonists |
|
|---|---|
| Cat No | Product Name / Activity |
| 2382 | EMD 386088 hydrochloride |
| Potent 5-HT6 agonist | |
| 4209 | EMDT oxalate |
| Selective 5-HT6 agonist | |
| 4337 | ST 1936 oxalate |
| Selective, high affinity 5-HT6 agonist | |
| 5589 | WAY 181187 oxalate |
| High affinity and selective 5-HT6 agonist | |
| 3904 | WAY 208466 dihydrochloride |
| Selective 5-HT6 agonist | |
Antagonists |
|
| Cat No | Product Name / Activity |
| 3326 | BGC 20-761 |
| High affinity 5-HT6 antagonist | |
| 4208 | MS 245 oxalate |
| High affinity 5-HT6 antagonist | |
| 3285 | NPS ALX Compound 4a dihydrochloride |
| Potent and selective 5-HT6 antagonist | |
| 4964 | R 1485 dihydrochloride |
| Selective and high affinity 5-HT6 antagonist | |
| 2911 | Ro 04-6790 |
| Potent and selective 5-HT6 antagonist | |
| 1961 | SB 258585 hydrochloride |
| Potent, selective 5-HT6 antagonist | |
| 3368 | SB 271046 hydrochloride |
| Selective 5-HT6 antagonist; orally active | |
| 3189 | SB 399885 hydrochloride |
| Potent and selective 5-HT6 antagonist | |
| 3688 | SGS 518 oxalate |
| Selective 5-HT6 antagonist | |
Other |
|
| Cat No | Product Name / Activity |
| 0590 | Metergoline |
| Has moderate affinity for 5-HT6 and high affinity for 5-HT7. Also 5-HT1/5-HT2 antagonist | |
| 0558 | 2-Methyl-5-hydroxytryptamine hydrochloride |
| 5-HT3 agonist/potent 5-HT6 ligand | |
| 0997 | Mianserin hydrochloride |
| Has moderate affinity for 5-HT6. Also 5-HT2 antagonist | |
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has been localized to chromosome 1 (1p35-36).
External sources of pharmacological information for 5-HT6 Receptors :
Literature for 5-HT6 Receptors
Tocris offers the following scientific literature for 5-HT6 Receptors to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
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Neurodegeneration Product Guide
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's Poster
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.
Our Neurodegeneration guide highlights over 275 products for neurodegeneration research.
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Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes.
Request copyDownload PDFWritten by Alan Palmer
Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease.
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