WAY 181187 oxalate

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Cat.No. 5589 - WAY 181187 oxalate | C15H13ClN4O2S2.C2H2O4 | CAS No. 1883548-85-3
Description: High affinity and selective 5-HT6 agonist
Chemical Name: 1-[(6-Chloroimidazo[2,1-b]thiazol-5-yl)sulfonyl]-1H-indole-3-ethanamine oxalate
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for WAY 181187 oxalate

WAY 181187 oxalate is a high affinity and selective 5-HT6 agonist (Ki = 2.2 nM). Displays 60-fold selectivity over other 5-HT and monoamine receptors. Increases firing rate of 5-HT neurons. Modifies sleep and wakefulness profiles following direct injections into the dorsal raphe nucleus, in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for WAY 181187 oxalate

WAY 181187 oxalate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 181187 oxalate

M. Wt 470.91
Formula C15H13ClN4O2S2.C2H2O4
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1883548-85-3
PubChem ID 121513871
Smiles NCCC2=CN(S(C3=C(Cl)N=C4N3C=CS4)(=O)=O)C1=CC=CC=C12.O=C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 181187 oxalate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 47.09 100

Preparing Stock Solutions for WAY 181187 oxalate

The following data is based on the product molecular weight 470.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.62 mL 21.24 mL
5 mM 0.42 mL 2.12 mL 4.25 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets for WAY 181187 oxalate

Certificate of Analysis / Product Datasheet
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References for WAY 181187 oxalate

References are publications that support the biological activity of the product.

Brouard et al (2015) Pharmacological evidence for 5-HT6 receptor modulation of 5-HT neuron firing in Vivo. ACS Chem.Neurosci. 6 1241 PMID: 25837696

Cole et al (2007) Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist. J.Med.Chem. 50 5535 PMID: 17948978

If you know of a relevant reference for WAY 181187 oxalate, please let us know.

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