SB 258585 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1961 - SB 258585 hydrochloride | C18H22IN3O3S.HCl | CAS No. 1216468-02-8
Description: Potent, selective 5-HT6 antagonist
Chemical Name: 4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective 5-HT6 receptor antagonist (pKi = 8.6); displays > 160-fold selectivity over other 5-HT receptor subtypes.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 523.82
Formula C18H22IN3O3S.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1216468-02-8
PubChem ID 53429667
InChI Key BFGOZFXMAJBFGI-UHFFFAOYSA-N
Smiles Cl.COC1=CC=C(NS(=O)(=O)C2=CC=C(I)C=C2)C=C1N1CCN(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.19 50
water 5.24 10

Preparing Stock Solutions

The following data is based on the product molecular weight 523.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.09 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.95 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bromidge et al (1999) 5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046): a potent, selective, and orally bioavailable 5-HT6 receptor antagonist. J.Med.Chem. 42 202 PMID: 9925723

East et al (2002) 5-HT6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [125I]SB-258585. Synapse 45 191 PMID: 12112397

Hirst et al (2000) Characterization of [125I]-SB-258585 binding to human recombinant and native 5-HT6 receptors in rat, pig and human brain tissue. Br.J.Pharmacol. 130 1597 PMID: 10928963


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Keywords: SB 258585 hydrochloride, supplier, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, SB258585, hydrochloride, GlaxoSmithKline, GSK, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience

1 Citation for SB 258585 hydrochloride

Citations are publications that use Tocris products. Selected citations for SB 258585 hydrochloride include:

Yun et al (2016) Peripheral serotonin-mediated system suppresses bone development and regeneration via serotonin 6 G-protein-coupled receptor. Scientific Reports 6 30985 PMID: 27581523


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