EMD 386088 hydrochloride

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Cat.No. 2382 - EMD 386088 hydrochloride | C14H15N2Cl.HCl | CAS No. 1171123-46-8
Description: Potent 5-HT6 agonist
Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM).

Compound Libraries

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Technical Data

M. Wt 283.2
Formula C14H15N2Cl.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1171123-46-8
PubChem ID 56972198
InChI Key WWSNDUWIZDYGIQ-UHFFFAOYSA-N
Smiles Cl.CC1=C(C2=CC(Cl)=CC=C2N1)C1=CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.08 25
DMSO 28.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 283.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.66 mL 35.31 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.77 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists. Bioorg.Med.Chem.Lett. 15 4230 PMID: 16055331


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3 Citations for EMD 386088 hydrochloride

Citations are publications that use Tocris products. Selected citations for EMD 386088 hydrochloride include:

Riccio et al (2011) Excess of serotonin affects neocortical pyramidal neuron migration. Transl Psychiatry 1 e47 PMID: 22833193

Hirono (2017) Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology 118 79 PMID: 28300552

Ly et al (2013) Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation. ACS Chem Neurosci 4 191 PMID: 23336058


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Literature in this Area

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