SB 399885 hydrochloride

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Cat.No. 3189 - SB 399885 hydrochloride | C18H21Cl2N3O4S.HCl | CAS No. 402713-81-9
Description: Potent and selective 5-HT6 antagonist
Chemical Name: N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Potent, brain penetrant, orally active 5-HT6 antagonist. Displays > 200-fold selectivity for 5-HT6 over other 5-HT receptors (pKi values are 9.11, 8.81 and 9.02 for human recombinant, native rat and native human 5-HT6 receptors respectively).

Compound Libraries

SB 399885 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 482.81
Formula C18H21Cl2N3O4S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 402713-81-9
PubChem ID 6918649
InChI Key ATKZKAYWARYLBW-UHFFFAOYSA-N
Smiles Cl.ClC1=CC(Cl)=CC(NS(C2=CC(N3CCNCC3)=C(OC)C=C2)(=O)=O)=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 48.28 100
DMSO 48.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 482.81. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.36 mL 20.71 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Wesolowska and Nikiforuk (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 1274 PMID: 17320917

Foley et al (2008) The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166 PMID: 18455201

Hirst et al (2006) SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur.J.Pharm. 553 109


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1 Citation for SB 399885 hydrochloride

Citations are publications that use Tocris products. Selected citations for SB 399885 hydrochloride include:

Garfield et al (2014) Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia. J Exp Med 266 201 PMID: 24566060


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Literature in this Area

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