5-HT7 Receptors

Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, thermoregulation, learning and memory and smooth muscle relaxation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1968 AS 19
Potent 5-HT7 agonist
2925 LP 12 hydrochloride
5-HT7 agonist
2534 LP 44
High affinity 5-HT7 agonist

Antagonists

Cat No Product Name / Activity
5005 DR 4485 hydrochloride
High affinity and selective 5-HT7 antagonist; orally bioavailable
1523 LY 215840
5-HT2/5-HT7 antagonist
2726 SB 258719 hydrochloride
Selective 5-HT7 antagonist
1612 SB 269970 hydrochloride
Potent and selective 5-HT7 antagonist; brain penetrant

Other

Cat No Product Name / Activity
0458 5-Carboxamidotryptamine maleate
Has high affinity for 5-ht5A and 5-HT7. Also 5-HT1 agonist
0529 8-Hydroxy-DPAT hydrobromide
Has moderate affinity for 5-HT7; also 5-HT1A agonist
4704 LP 20 hydrochloride
Selective 5-HT7 ligand
0590 Metergoline
Has moderate affinity for 5-HT6 and high affinity for 5-HT7. Also 5-HT1/5-HT2 antagonist
0937 Pimozide
High affinity for 5-HT7. Also D2 antagonist

Serotonin 5-HT7 receptors are located primarily in the thalamus, hypothalamus and hippocampus. The function of these receptors includes the regulation of circadian rhythms, learning and memory and smooth muscle relaxation. The human 5-HT7 receptor gene has been localized to chromosome 10 (10q21-24).

External sources of pharmacological information for 5-HT7 Receptors :

Literature for 5-HT7 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

5-HT7 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR7 NM_000872 P34969
Mouse Htr7 NM_008315 P32304
Rat Htr7 NM_022938 P32305