5-HT4 Receptors

Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
4374 BIMU 8
Potent 5-HT4 receptor full agonist
1695 Cisapride
5-HT4 agonist; stimulates intestinal ACh release
3089 CJ 033466
Selective 5-HT4 partial agonist
3499 ML 10302 hydrochloride
Potent and selective 5-HT4 partial agonist
2844 Mosapride citrate
5-HT4 agonist and 5-HT3 antagonist
0736 2-[1-(4-Piperonyl)piperazinyl]benzothiazole
5-HT4 agonist. Also 5-HT3 antagonist
0989 RS 67333 hydrochloride
5-HT4 partial agonist
0990 RS 67506 hydrochloride
5-HT4 partial agonist
4613 Tegaserod maleate
5-HT4 partial agonist
1795 Zacopride hydrochloride
5-HT4 agonist. Also highly potent 5-HT3 antagonist

Antagonists

Cat No Product Name / Activity
1322 GR 113808
Potent, selective 5-HT4 antagonist
1658 GR 125487 sulfamate
Potent, selective 5-HT4 antagonist; active in vivo
0728 RS 23597-190 hydrochloride
5-HT4 antagonist
0991 RS 39604 hydrochloride
5-HT4 antagonist
0785 SB 203186 hydrochloride
5-HT4 antagonist
1373 SB 204070
Potent and selective 5-HT4 antagonist
2037 SDZ 205-557 hydrochloride
5-HT4/5-HT3 receptor antagonist

Serotonin 5-HT4 receptors are located primarily in nigrostriatal and mesolimbic systems and smooth muscle. The receptor plays a role in memory and learning, anxiety, visual perception and smooth muscle relaxation. The human 5-HT4 receptor gene has been localized to chromosome 5 (5q31-33).

External sources of pharmacological information for 5-HT4 Receptors :

Literature for 5-HT4 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

5-HT4 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR4 NM_000870 Q13639
Mouse Htr4 NM_008313 P97288
Rat Htr4 NM_012853 Q62758