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Biological Activity for BGC 20-761
BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.
Compound Libraries for BGC 20-761
Technical Data for BGC 20-761
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for BGC 20-761
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for BGC 20-761
The following data is based on the product molecular weight 294.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.4 mL||16.98 mL||33.97 mL|
|5 mM||0.68 mL||3.4 mL||6.79 mL|
|10 mM||0.34 mL||1.7 mL||3.4 mL|
|50 mM||0.07 mL||0.34 mL||0.68 mL|
References for BGC 20-761
References are publications that support the biological activity of the product.
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Mitchell et al (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412 PMID: 16298400
If you know of a relevant reference for BGC 20-761, please let us know.
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Keywords: BGC 20-761, BGC 20-761 supplier, 5ht, 5-hydroxytryptamine, serotonin, 5ht6, high, affinity, ligands, BGC20761, 5-HT6, Receptors, 3326, Tocris Bioscience
Citations for BGC 20-761
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Reviews for BGC 20-761
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.