BGC 20-761

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Description: High affinity 5-HT6 antagonist
Chemical Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for BGC 20-761

BGC 20-761 is a selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.

Technical Data for BGC 20-761

M. Wt 294.39
Formula C19H22N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 17375-63-2
PubChem ID 6918515
Smiles CN(CCC2=C(C3=CC=CC=C3)NC1=CC=C(OC)C=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for BGC 20-761

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.44 100
ethanol 14.72 50

Preparing Stock Solutions for BGC 20-761

The following data is based on the product molecular weight 294.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References for BGC 20-761

References are publications that support the biological activity of the product.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Mitchell et al (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412 PMID: 16298400

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Keywords: BGC 20-761, BGC 20-761 supplier, 5ht, 5-hydroxytryptamine, serotonin, 5ht6, high, affinity, ligands, BGC20761, 5-HT6, Receptors, 3326, Tocris Bioscience

Citations for BGC 20-761

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.