BGC 20-761

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Cat.No. 3326 - BGC 20-761 | C19H22N2O | CAS No. 17375-63-2
Description: High affinity 5-HT6 antagonist
Chemical Name: 5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, high affinity 5-HT6 antagonist (Ki = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.

Technical Data

M. Wt 294.39
Formula C19H22N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 17375-63-2
PubChem ID 6918515
InChI Key VSGPGYWZVPDDSK-UHFFFAOYSA-N
Smiles CN(CCC2=C(C3=CC=CC=C3)NC1=CC=C(OC)C=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.44 100
ethanol 14.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 294.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.4 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.4 mL 6.79 mL
10 mM 0.34 mL 1.7 mL 3.4 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164

Mitchell et al (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412 PMID: 16298400


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Keywords: BGC 20-761, supplier, 5ht, 5-hydroxytryptamine, serotonin, 5ht6, high, affinity, ligands, BGC20761, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience

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