PRX 07034

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Cat.No. 6748 - PRX 07034 | C21H28ClN3O4S.HCl | CAS No. 903580-39-2
Description: Potent and selective 5-HT6 antagonist
Chemical Name: N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Potent and selective 5-HT6 receptor antagonist (IC50 = 19 nM, Ki = 4 - 8 nM). Enhances working memory in rats.

Technical Data

M. Wt 490.44
Formula C21H28ClN3O4S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 903580-39-2
PubChem ID 23653584
Smiles ClC1=CC(C(NC2=C(S(C)(=O)=O)C=CC(N3CCNCC3)=C2)C)=C(OC)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 9.81 20 with gentle warming
DMSO 49.04 100

Preparing Stock Solutions

The following data is based on the product molecular weight 490.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References are publications that support the biological activity of the product.

Mohler et al (2012) The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 220 687 PMID: 21989804

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