PRX 07034

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Description: Potent and selective 5-HT6 antagonist
Chemical Name: N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for PRX 07034

PRX 07034 is a potent and selective 5-HT6 receptor antagonist (IC50 = 19 nM, Ki = 4 - 8 nM). Enhances working memory in rats.

Compound Libraries for PRX 07034

PRX 07034 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PRX 07034

M. Wt 490.44
Formula C21H28ClN3O4S.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 903580-39-2
PubChem ID 23653584
InChI Key PILCQJJJAFRKHO-UHFFFAOYSA-N
Smiles ClC1=CC(C(NC2=C(S(C)(=O)=O)C=CC(N3CCNCC3)=C2)C)=C(OC)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for PRX 07034

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.81 20 with gentle warming
DMSO 49.04 100

Preparing Stock Solutions for PRX 07034

The following data is based on the product molecular weight 490.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.19 mL 20.39 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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References for PRX 07034

References are publications that support the biological activity of the product.

Mohler et al (2012) The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 220 687 PMID: 21989804


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Keywords: PRX 07034, PRX 07034 supplier, PRX07034, potent, selective, serotonergic, 5HT6, receptor, 5-HT, antagonists, antagonism, 5-HT6, Receptors, 6748, Tocris Bioscience

Citations for PRX 07034

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Reviews for PRX 07034

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.