5-ht5 Receptors

Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents, but a functional transcript has not been identified in humans.

Products
Background
Literature
Gene Data

Antagonists

Cat No Product Name / Activity
3188 SB 699551
Selective 5-ht5a antagonist

Other

Cat No Product Name / Activity
0458 5-Carboxamidotryptamine maleate
Has high affinity for 5-ht5A and 5-HT7. Also 5-HT1 agonist

Serotonin 5-ht5 receptors are G-protein-coupled receptors that preferentially couple to Gs and promote cAMP formation. Two 5-ht5 receptor subtypes (5-ht5a and 5-ht5b) have been found in rodents, but a functional transcript of the 5-ht5a receptor has not been identified in humans.

External sources of pharmacological information for 5-ht5 Receptors :

Literature for 5-ht5 Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

5-ht5 Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
5-ht5A Human HTR5A NM_024012 P47898
Mouse Htr5a NM_008314 P30966
Rat Htr5b NM_013148 P35364
5-ht5B Human HTR5B XR_017010 Q9P2D3
Mouse Htr5b NM_010483 P31387
Rat Htr5b XM_341111 P35365