WAY 208466 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3904 - WAY 208466 dihydrochloride | C17H18FN3O2S.2HCl | CAS No. 1207064-61-6
Description: Selective 5-HT6 agonist
Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

WAY 208466 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 420.33
Formula C17H18FN3O2S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1207064-61-6
PubChem ID 22028182
InChI Key BAOHMLBVCLITHA-UHFFFAOYSA-N
Smiles O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.63 80
water 33.63 80

Preparing Stock Solutions

The following data is based on the product molecular weight 420.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.9 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Schechter et al (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 33 1323 PMID: 17625499

Carr et al (2010) Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 213 49 PMID: 20217056


If you know of a relevant reference for WAY 208466 dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT6 Receptor Agonists

Keywords: WAY 208466 dihydrochloride, supplier, WAY208466, 2HCl, serotonin, receptor, subtype, 5-hydroxytryptamine, 6, agonist, 5-HT6, agonists, 5-HT6, Receptors, 5-HT6, Receptors, Tocris Bioscience

Citations for WAY 208466 dihydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for WAY 208466 dihydrochloride. Do you know of a great paper that uses WAY 208466 dihydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Alzheimer's

Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for WAY 208466 dihydrochloride

Protocols

TODO: Add Protocols