WAY 208466 dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3904 - WAY 208466 dihydrochloride | C17H18FN3O2S.2HCl | CAS No. 1207064-61-6
Description: Selective 5-HT6 agonist
Chemical Name: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity, selective 5-HT6 agonist (EC50 = 7.3 nM at the human 5-HT6 receptor). Elevates cortical GABA levels in vivo in rat frontal cortex. Exhibits antidepressant and anxiolytic-like effects.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

WAY 208466 dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 420.33
Formula C17H18FN3O2S.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1207064-61-6
PubChem ID 22028182
InChI Key BAOHMLBVCLITHA-UHFFFAOYSA-N
Smiles O=S(C2=CN(CCN(C)C)C1=NC=CC=C12)(C3=CC=CC(F)=C3)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.63 80
DMSO 33.63 80

Preparing Stock Solutions

The following data is based on the product molecular weight 420.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.9 mL 23.79 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Schechter et al (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacol 33 1323 PMID: 17625499

Carr et al (2010) Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats. Psychopharmacol.(Berl.) 213 49 PMID: 20217056


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Citations for WAY 208466 dihydrochloride

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