BIMU 8

Pricing Availability Delivery Time Qty
Cat.No. 4374 - BIMU 8 | C19H26N4O2.HCl | CAS No. 134296-40-5
Description: Potent 5-HT4 receptor full agonist
Chemical Name: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent 5-HT4 receptor full agonist (KD = 77 nM and EC50 = 18 nM for wild type 5-HT4 receptors). Binds to receptors in a mechanism different to that of the endogenous ligand 5-HT.

Compound Libraries

BIMU 8 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 378.9
Formula C19H26N4O2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 134296-40-5
PubChem ID 5311028
InChI Key NQYXXIUVFVOJCX-XZPOUAKSSA-N
Smiles [H][C@]12CC[C@](CC(NC(N3C(C=CC=C4)=C4N(C(C)C)C3=O)=O)C2)([H])N1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.89 100
water 28.42 75

Preparing Stock Solutions

The following data is based on the product molecular weight 378.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.2 mL 26.39 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Pellissier et al (2009) Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors. Mol.Pharmacol. 75 982 PMID: 19168624

Schaus et al (1998) Synthesis and structure-activity relationships of potent and orally active 5-HT4 receptor antagonists: Indazole and benzimidazoline derivatives. J.Med.Chem. 41 1943 PMID: 9599243


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Keywords: BIMU 8, supplier, BIMU8, 5-hydroxytryptamine, 4, 5HT4, receptors, 5-HT4, receptors, agonists, serotonin, serotonergic, 4, 5-HT4, Receptors, 5-HT4, Receptors, Tocris Bioscience

2 Citations for BIMU 8

Citations are publications that use Tocris products. Selected citations for BIMU 8 include:

Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336 PMID: 27874067

House et al (2015) Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. PLoS One 29 323 PMID: 25342126


Do you know of a great paper that uses BIMU 8 from Tocris? If so please let us know.

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Literature in this Area

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Pathways for BIMU 8

Protocols

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