RS 23597-190 hydrochloride
A high affinity, selective competitive antagonist at 5-HT4 receptors.
Sold with the permission of Roche Bioscience
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 363.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.75 mL||13.76 mL||27.53 mL|
|5 mM||0.55 mL||2.75 mL||5.51 mL|
|10 mM||0.28 mL||1.38 mL||2.75 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
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3 Citations for RS 23597-190 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111 PMID: 17376972
Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527
Do you know of a great paper that uses RS 23597-190 hydrochloride from Tocris? If so please let us know.
Literature in this Area
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.