RS 23597-190 hydrochloride

Pricing Availability   Qty
Description: 5-HT4 antagonist
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Citations (5)
Literature (2)

Biological Activity for RS 23597-190 hydrochloride

RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT4 receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data for RS 23597-190 hydrochloride

M. Wt 363.28
Formula C16H23ClN2O3.HCl
Storage Store at RT
CAS Number 149719-06-2
PubChem ID 182592

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RS 23597-190 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for RS 23597-190 hydrochloride

The following data is based on the product molecular weight 363.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.53 mL
5 mM 0.55 mL 2.75 mL 5.51 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for RS 23597-190 hydrochloride

References for RS 23597-190 hydrochloride

References are publications that support the biological activity of the product.

Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

If you know of a relevant reference for RS 23597-190 hydrochloride, please let us know.

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5 Citations for RS 23597-190 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:

Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222

Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527

Xiang et al (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93 1145 PMID: 15738272

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Do you know of a great paper that uses RS 23597-190 hydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.