RS 23597-190 hydrochloride

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Cat.No. 0728 - RS 23597-190 hydrochloride | C16H23ClN2O3.HCl | CAS No. 149719-06-2
Description: 5-HT4 antagonist
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Datasheet
Citations (3)
Literature

Biological Activity

A high affinity, selective competitive antagonist at 5-HT4 receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 363.28
Formula C16H23ClN2O3.HCl
Storage Store at RT
CAS Number 149719-06-2
PubChem ID 182592
InChI Key QLZLBYYNMGQIAR-UHFFFAOYSA-N
Smiles Cl.COC1=CC(N)=C(Cl)C=C1C(=O)OCCCN1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 363.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.53 mL
5 mM 0.55 mL 2.75 mL 5.51 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609


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Keywords: 5-HT4 antagonists Serotonin Receptors 5-Hydroxytryptamine 5-HT RS23597-190 hydrochloride 5-HT4 Receptors

3 Citations for RS 23597-190 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111 PMID: 17376972

Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527


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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

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