RS 23597-190 hydrochloride

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Cat.No. 0728 - RS 23597-190 hydrochloride | C16H23ClN2O3.HCl | CAS No. 149719-06-2
Description: 5-HT4 antagonist
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Citations (5)

Biological Activity

A high affinity, selective competitive antagonist at 5-HT4 receptors.

Licensing Information

Sold with the permission of Roche Bioscience

Technical Data

M. Wt 363.28
Formula C16H23ClN2O3.HCl
Storage Store at RT
CAS Number 149719-06-2
PubChem ID 182592

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in water

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References are publications that support the biological activity of the product.

Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871

Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609

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5 Citations for RS 23597-190 hydrochloride

Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:

Xiang et al (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93 1145 PMID: 15738272

Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222

Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111 PMID: 17376972

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527

Do you know of a great paper that uses RS 23597-190 hydrochloride from Tocris? Please let us know.

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