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Cat.No. 1695 - Cisapride | C23H29ClFN3O4 | CAS No. 81098-60-4
Description: 5-HT4 agonist; stimulates intestinal ACh release
Alternative Names: R 51619
Chemical Name: (±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

5-HT4 receptor agonist and gastrokinetic agent. Stimulates intestinal acetylcholine release, possibly via 5-HT4 receptor-dependent and -independent mechanisms, leading to increased intestinal motility.

Compound Libraries

Cisapride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 465.95
Formula C23H29ClFN3O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 81098-60-4
PubChem ID 6917698
Smiles CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.59 100

Preparing Stock Solutions

The following data is based on the product molecular weight 465.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.73 mL 21.46 mL
5 mM 0.43 mL 2.15 mL 4.29 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Briejer et al (1993) Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens. Naunyn Schmiedebergs Arch.Pharmacol. 347 464 PMID: 8321323

Schuurkes et al (1985) Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J.Pharmacol.Exp.Ther. 234 775 PMID: 3897516

Taniyama et al (1991) Cisapride stimulates motility of the intestine via the 5-hydroxytryptamine receptors. J.Pharmacol.Exp.Ther. 258 1098 PMID: 1890614

If you know of a relevant reference for Cisapride, please let us know.

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View all 5-HT4 Receptor Agonists

Keywords: 5-HT4 agonists stimulates Serotonin Receptors 5-Hydroxytryptamine stimulate ACh acetylcholine release nicotinic muscarinic nAChR R51619 R 51619 5-HT4 Receptors

1 Citation for Cisapride

Citations are publications that use Tocris products. Selected citations for Cisapride include:

Padayatti et al (2013) A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics 12 1259 PMID: 23378516

Do you know of a great paper that uses Cisapride from Tocris? If so please let us know.

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