Zacopride hydrochloride

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Description: Highly potent 5-HT3 antagonist; also 5-HT4 agonist
Chemical Name: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (1)

Biological Activity for Zacopride hydrochloride

Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist (Ki = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

Compound Libraries for Zacopride hydrochloride

Zacopride hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Zacopride hydrochloride

M. Wt 346.26
Formula C15H20ClN3O2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 101303-98-4
PubChem ID 9928181
Smiles Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)NC1CN2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zacopride hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 34.63 100
DMSO 34.62 100

Preparing Stock Solutions for Zacopride hydrochloride

The following data is based on the product molecular weight 346.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.44 mL 28.88 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.44 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Product Datasheets for Zacopride hydrochloride

Certificate of Analysis / Product Datasheet
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References for Zacopride hydrochloride

References are publications that support the biological activity of the product.

Cohen et al (1989) Comparison of the 5-HT3 receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 248 197 PMID: 2521513

Costall et al (1988) Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 40 302 PMID: 2900320

Kii and Ito (1997) Effects of 5-HT4-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 29 670 PMID: 9213211

Nagakura et al (1999) Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol.Res. 39 375 PMID: 10328995

If you know of a relevant reference for Zacopride hydrochloride, please let us know.

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3 Citations for Zacopride hydrochloride

Citations are publications that use Tocris products. Selected citations for Zacopride hydrochloride include:

Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336 PMID: 27874067

Ding et al (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Toxins (Basel) 29 725 PMID: 25922425

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Circulation 7 2336 PMID: 26114334

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.