5-HT2B Receptors

Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. 5-HT2B overexpression leads to ventricular hypertrophy.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
1059 BW 723C86 hydrochloride
5-HT2B agonist
0875 m-CPP hydrochloride
5-HT2B/2C receptor agonist
0557 α-Methyl-5-hydroxytryptamine maleate
5-HT2B agonist

Antagonists

Cat No Product Name / Activity
3346 ATC 0175 hydrochloride
MCH1 antagonist; also 5-HT2B antagonist and 5-HT1A partial agonist
4081 LY 266097 hydrochloride
Selective 5-HT2B receptor antagonist
3077 LY 272015 hydrochloride
High affinity 5-HT2B antagonist; orally active
2993 RS 127445 hydrochloride
Selective, high affinity 5-HT2B antagonist
1371 SB 200646 hydrochloride
5-HT2C/2B antagonist
1372 SB 204741
Potent, selective 5-HT2B antagonist
1661 SB 206553 hydrochloride
Potent, selective 5-HT2C/5-HT2B antagonist. Orally active
1374 SB 215505
5-HT2B/2C antagonist
1379 SB 221284
Potent, selective 5-HT2C/2B antagonist
1375 SB 228357
5-HT2C/2B antagonist/inverse agonist
1255 SDZ SER 082 fumarate
Selective 5-HT2B/2C antagonist

Serotonin 5-HT2B receptors, previously known as 5-HT2F receptors, are located primarily in the stomach fundus, uterus, vascular endothelial and vascular and GI smooth muscle, with limited distribution in the brain. The functions of 5-HT2B receptors include regulation of differentiation and proliferation of the embryonic and adult heart, gastrointestinal contraction and endothelium-dependent relaxation. Furthermore, 5-HT2B receptor knockout mice exhibit gross heart defects and 5-HT2B overexpression leads to ventricular hypertrophy. The human 5-HT2B receptor gene has been localized to chromosome 2 (2q36.3-q37.1).

External sources of pharmacological information for 5-HT2B Receptors :

Literature for 5-HT2B Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

5-HT2B Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR2B NM_000867 P41595
Mouse Htr2b NM_008311 Q02152
Rat Htr2b NM_017250 P30994