LY 266097 hydrochloride

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Cat.No. 4081 - LY 266097 hydrochloride | C21H23ClN2O2.HCl | CAS No. 172895-39-5
Description: Selective 5-HT2B receptor antagonist
Chemical Name: 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT2B receptor antagonist (pKi = 9.3). More than 100-fold selective over 5-HT2A and 5-HT2C. Attenuates amphetamine-induced locomotion in the rat.

Compound Libraries

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Technical Data

M. Wt 407.33
Formula C21H23ClN2O2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 172895-39-5
PubChem ID 9953184
InChI Key KPXKZZURYAXZQE-UHFFFAOYSA-N
Smiles CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4Cl)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.73 100
ethanol 40.73 100

Preparing Stock Solutions

The following data is based on the product molecular weight 407.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.28 mL 24.55 mL
5 mM 0.49 mL 2.46 mL 4.91 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Audia et al (1996) Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5-HT2B) contractile receptor in the rat stomach fundus. J.Med.Chem. 39 2773 PMID: 8709108

Auclair et al (2010) The central serotonin2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J.Neurochem. 114 1323 PMID: 20534001


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Citations for LY 266097 hydrochloride

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