LY 272015 hydrochloride

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Cat.No. 3077 - LY 272015 hydrochloride | C21H24N2O2.HCl | CAS No. 172895-15-7
Description: High affinity 5-HT2B antagonist; orally active
Chemical Name: 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature (3)

Biological Activity

High affinity 5-HT2B receptor antagonist that displays selectivity over 5-HT2A and 5-HT2C receptors (Ki values are 0.75, 21.63 and 28.7 nM for 5-HT2B, 5-HT2C and 5-HT2A receptors respectively). Orally active.

Licensing Information

Sold under license from Eli Lilly and company

Compound Libraries

LY 272015 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 372.89
Formula C21H24N2O2.HCl
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 172895-15-7
PubChem ID 9929423
InChI Key BKAZOTIBKRWLQA-UHFFFAOYSA-N
Smiles CC1=CC=C(NC3=C2CCNC3CC4=CC=C(OC)C(OC)=C4)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.29 100
ethanol 3.73 10

Preparing Stock Solutions

The following data is based on the product molecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References

References are publications that support the biological activity of the product.

Sevoz-Couche et al (2000) In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine2 receptors in rat. Br.J.Pharmacol. 131 1445 PMID: 11090119

Cohen et al (1996) LY272015, a potent, selective and orally active 5-HT2B receptor antagonist. J.Serotonin Res. 3 131

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS One 6 e21395 PMID: 21789169


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Keywords: LY 272015 hydrochloride, LY 272015 hydrochloride supplier, High, affinity, 5-HT2B, antagonists, orally, active, Serotonin, Receptors, LY272015, hydrochloride, 3077, Tocris Bioscience

3 Citations for LY 272015 hydrochloride

Citations are publications that use Tocris products. Selected citations for LY 272015 hydrochloride include:

Soll et al (2012) Expression of serotonin receptors in human hepatocellular cancer. Clin Cancer Res 18 5902 PMID: 23087410

Niebert et al (2011) Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. J Pharmacol Exp Ther 6 e21395 PMID: 21789169

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. PLoS One 3 e00103 PMID: 25692021


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Reviews for LY 272015 hydrochloride

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5-HT has a potential for relaxant.
By Anonymous on 02/18/2020
Assay Type: In Vivo
Species: Rat

LY272015 (1 lmol/L)

PMID: 25692021
review image

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