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Biological Activity for CELT-211
CELT-211 is a potent and selective fluorescent h5HT2B serotonin receptor ligand. It shows full selectivity for h5HT2B over h5HT2A, h5HT2C (Ki values is 56.3 nM for h5HT2B receptors in radioligand binding assay). Excitation and emission maxima (λ) are 589 and 616 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.
Add 82 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.
Sold under license from Celtarys Research
Optical Data for CELT-211
|Application||Time-resolved fluorescence energy transfer (TR-FRET)|
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Technical Data for CELT-211
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for CELT-211
References are publications that support the biological activity of the product.
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Keywords: CELT-211, CELT-211 supplier, CELT211, potent, selective, 5HT2B, Serotonin, receptor, ligand, fluorescent, probe, fluorescence, TR-FRET, 5-HT2B, Receptors, and, FP, Assay, Reagents, Fluorescent, Receptor, Probes, 7953, Tocris Bioscience
Citations for CELT-211
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.