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Description: Fluorescent serotonin 5HT2B receptor ligand for HTS
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for CELT-211

CELT-211 is a potent and selective fluorescent h5HT2B serotonin receptor ligand. It shows full selectivity for h5HT2B over h5HT2A, h5HT2C (Ki values is 56.3 nM for h5HT2B receptors in radioligand binding assay). Excitation and emission maxima (λ) are 589 and 616 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

Add 82 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.

Scientific Data

Fluorescence Imaging Application of CELT-211 in CHO cells expressing the human 5HT<sub>2B</sub>R. View Larger

Application of CELT-211 in CHO cells expressing the human 5HT2BR. CHO cells expressing the human 5HT2BR labelled with CELT-211 (pink) at 56 nM and Hoechst 33342 (blue) (catalog # 5117) without (A) or with (B) 5-HT (50 µM) preincubation.

Licensing Information

Sold under license from Celtarys Research

Optical Data for CELT-211

λabs 589 nm
λem 616 nm
Application Time-resolved fluorescence energy transfer (TR-FRET)

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Technical Data for CELT-211

M. Wt 1330.22
Storage Store at -20°C
Purity ≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CELT-211

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Keywords: CELT-211, CELT-211 supplier, CELT211, potent, selective, 5HT2B, Serotonin, receptor, ligand, fluorescent, probe, fluorescence, TR-FRET, 5-HT2B, Receptors, and, FP, Assay, Reagents, Fluorescent, Receptor, Probes, 7953, Tocris Bioscience

Citations for CELT-211

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.