5-HT2C Receptors

Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3041 CP 809101 hydrochloride
Potent and selective 5-HT2C agonist
0875 m-CPP hydrochloride
5-HT2B/2C receptor agonist
2643 DOI hydrochloride
Mixed 5-HT2A/2C agonist
1860 Eltoprazine hydrochloride
5-HT2C receptor partial agonist
3017 1-Methylpsilocin
Potent and selective 5-HT2C agonist
0941 MK 212 hydrochloride
5-HT2C agonist
3585 Org 12962 hydrochloride
Selective 5-HT2C agonist
2201 PNU 22394 hydrochloride
5-HT2C agonist and 5-HT2A/2B partial agonist
1854 Ro 60-0175 fumarate
Potent, selective 5-HT2C agonist
0925 SCH 23390 hydrochloride
5-HT2C agonist; also potent dopamine D1-like antagonist, 5-HT1C agonist and Kir3 channel blocker
1801 WAY 161503 hydrochloride
Potent, selective 5-HT2C agonist
2173 WAY 629 hydrochloride
Selective 5-HT2C agonist

Antagonists

Cat No Product Name / Activity
0444 Clozapine
5-HT2A/2C antagonist. Also dopamine antagonist
4936 Clozapine N-oxide
Clozapine (Cat. No. 0444) metabolite
6329 Clozapine N-oxide dihydrochloride
Water soluble salt of Clozapine N-oxide (Cat. No. 4936)
1007 N-Desmethylclozapine
5-HT2C antagonist
1644 Mesulergine hydrochloride
5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist
1050 RS 102221 hydrochloride
Selective 5-HT2C antagonist
4508 S 32212 hydrochloride
5-HT2C inverse agonist; α2 antagonist
1371 SB 200646 hydrochloride
5-HT2C/2B antagonist
1661 SB 206553 hydrochloride
Potent, selective 5-HT2C/5-HT2B antagonist. Orally active
1374 SB 215505
5-HT2B/2C antagonist
1379 SB 221284
Potent, selective 5-HT2C/2B antagonist
1375 SB 228357
5-HT2C/2B antagonist/inverse agonist
2901 SB 242084
Selective 5-HT2C antagonist; brain penetrant
3527 SB 243213 dihydrochloride
Selective 5-HT2C inverse agonist
1255 SDZ SER 082 fumarate
Selective 5-HT2B/2C antagonist

Serotonin 5-HT2C receptors, previously known as 5-HT1C receptors, are located primarily in the choroid plexus, cortex, limbic system and basal ganglia. 5-HT2C receptors play a role in CSF volume regulation, thermoregulation, penile erection and anxiety. The human 5-HT2C receptor gene has been localized to chromosome X (Xq24).

External sources of pharmacological information for 5-HT2C Receptors :

Literature for 5-HT2C Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

5-HT2C Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR2C NM_000868 P28335
Mouse Htr2c NM_008312 P34968
Rat Htr2c NM_012765 P08909