5-HT2A Receptors

Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, hippocampus, and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in the control of appetite.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2643 DOI hydrochloride
Mixed 5-HT2A/2C agonist
5171 NBOH-2C-CN hydrochloride
High affinity, selective 5-HT2A agonist
2201 PNU 22394 hydrochloride
5-HT2C agonist and 5-HT2A/2B partial agonist
2592 TCB-2
Potent, high affinity 5-HT2A agonist

Antagonists

Cat No Product Name / Activity
1809 Altanserin hydrochloride
5-HT2A receptor antagonist
5584 Aripiprazole
5-HT2A antagonist; also D2 and 5-HT1A receptor partial agonist
4468 AT 1015
Long-acting 5-HT2A antagonist
0444 Clozapine
5-HT2A/2C antagonist. Also dopamine antagonist
4936 Clozapine N-oxide
Clozapine (Cat. No. 0444) metabolite
3428 DMT
5-HT2A antagonist. Also SERT inhibitor and endogenous σ1 ligand
4480 DV 7028 hydrochloride
Selective 5-HT2A antagonist; antithrombotic
4470 EMD 281014 hydrochloride
Selective 5-HT2A antagonist
4958 Eplivanserin hemifumarate
Potent and selective 5-HT2A antagonist
0523 4F 4PP oxalate
Selective 5-HT2A antagonist
2645 Fananserin
5-HT2A antagonist. Also D4 antagonist
0908 Ketanserin tartrate
Selective 5-HT2A antagonist. Also antagonist at 5-HT1D
4173 MDL 100907
Potent and selective 5-HT2A antagonist
0870 MDL 11,939
5-HT2A antagonist
2495 Melperone hydrochloride
5-HT2A/D2 receptor antagonist; neuroleptic
1644 Mesulergine hydrochloride
5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist
2777 Nefazodone hydrochloride
5-HT2A antagonist and 5-HT uptake inhibitor. Antidepressant
4493 Paliperidone
Atypical antipsychotic; 5-HT2A and D2 antagonist
2735 PNU 96415E
5-HT2A and D4 antagonist; antipsychotic
1742 R-96544 hydrochloride
Potent, selective 5-HT2A antagonist
2865 Risperidone
5-HT2A antagonist
3739 Sarpogrelate hydrochloride
Selective 5-HT2A antagonist
0995 Spiperone hydrochloride
5-HT2A antagonist. Also D2-like antagonist
6336 Trazodone hydrochloride
5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation; antidepressant and neuroprotectant
3085 Ziprasidone hydrochloride
5-HT2A/D2 antagonist; atypical antipsychotic
3996 Zotepine
5-HT2A/D2 antagonist; atypical antipsychotic

Serotonin 5-HT2A receptors, previously known as 5-HT2 receptors, are located primarily in the neocortex, caudate nucleus, nucleus accumbens, hippocampus, and vascular and non-vascular smooth muscle cells. 5-HT2A receptors play a role in sleep and the control of appetite.

External sources of pharmacological information for 5-HT2A Receptors :

Literature for 5-HT2A Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.

5-HT2A Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human HTR2A NM_000621 P28223
Mouse Htr2a NM_172812 P35363
Rat Htr2a NM_017254 P14842