NBOH-2C-CN hydrochloride

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Description: High affinity and selective 5-HT2A agonist
Alternative Names: 25CN-NBOH
Chemical Name: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride
Purity: ≥98% (HPLC)
Citations (2)
Literature (3)

Biological Activity for NBOH-2C-CN hydrochloride

NBOH-2C-CN hydrochloride is a high affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.

Technical Data for NBOH-2C-CN hydrochloride

M. Wt 348.82
Formula C18H20N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1539266-32-4
PubChem ID 90489019
Smiles OC(C=CC=C2)=C2CNCCC1=C(OC)C=C(C#N)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NBOH-2C-CN hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 3.49 10 with gentle warming
DMSO 34.88 100

Preparing Stock Solutions for NBOH-2C-CN hydrochloride

The following data is based on the product molecular weight 348.82. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.33 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets for NBOH-2C-CN hydrochloride

Certificate of Analysis / Product Datasheet
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Keywords: NBOH-2C-CN hydrochloride, NBOH-2C-CN hydrochloride supplier, serotonin, potent, selective, high, affinity, 5-ht, 5-ht2a, agonists, receptors, hallucinogen-like, 25CN-NBOH, 5-HT2A, Receptors, 5171, Tocris Bioscience

2 Citations for NBOH-2C-CN hydrochloride

Citations are publications that use Tocris products. Selected citations for NBOH-2C-CN hydrochloride include:

Wieland B et al (2020) Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron 108 1113-1129.e6 PMID: 33080227

Hongyan et al (2022) Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord. Curr Biol 32 1038-1048.e2 PMID: 35104440

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.