NBOH-2C-CN hydrochloride

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Cat.No. 5171 - NBOH-2C-CN hydrochloride | C18H20N2O3.HCl | CAS No. 1539266-32-4
Description: High affinity, selective 5-HT2A agonist
Alternative Names: 25CN-NBOH
Chemical Name: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.

Technical Data

M. Wt 348.82
Formula C18H20N2O3.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1539266-32-4
PubChem ID 90489019
InChI Key JQVAEIIIMVMJBO-UHFFFAOYSA-N
Smiles OC(C=CC=C2)=C2CNCCC1=C(OC)C=C(C#N)C(OC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.88 100
water 3.49 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 348.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.33 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hansen et al (2014) Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS.Chem.Neurosci. 5 243 PMID: 24397362

Fantegrossi et al (2014) Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. Psychopharmacology (Berl.) 232 1039 PMID: 25224567


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Keywords: serotonin potent selective high affinity 5-ht 5-ht2a agonists receptors hallucinogen-like 25CN-NBOH 5-HT2A Receptors

Citations for NBOH-2C-CN hydrochloride

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