MDL 100907

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Cat.No. 4173 - MDL 100907 | C22H28FNO3 | CAS No. 139290-65-6
Description: Potent and selective 5-HT2A antagonist
Alternative Names: Volinanserin
Chemical Name: (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
Purity: ≥98% (HPLC)
Datasheet
Citations (8)
Reviews
Literature (6)

Biological Activity for MDL 100907

MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM, IC50 = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo.

Compound Libraries for MDL 100907

MDL 100907 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MDL 100907

M. Wt 373.46
Formula C22H28FNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 139290-65-6
PubChem ID 5311271
InChI Key HXTGXYRHXAGCFP-OAQYLSRUSA-N
Smiles FC(C=C3)=CC=C3CCN(CC2)CCC2[C@@H](O)C1=C(OC)C(OC)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MDL 100907

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 18.67 50
DMSO 37.35 100

Preparing Stock Solutions for MDL 100907

The following data is based on the product molecular weight 373.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.39 mL 26.78 mL
5 mM 0.54 mL 2.68 mL 5.36 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for MDL 100907

Certificate of Analysis / Product Datasheet
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Keywords: MDL 100907, MDL 100907 supplier, MDL100907, potent, selective, 5-HT2A, receptors, antagonists, 5HT2A, antipsychotic, dopaminergic, neuroprotective, neuroprotection, volinanserin, M100907, Volinanserin, Receptors, 4173, Tocris Bioscience

8 Citations for MDL 100907

Citations are publications that use Tocris products. Selected citations for MDL 100907 include:

Athilingam et al (2017) Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. Elife 6 PMID: 29206101

Grønli et al (2016) Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep 39 2189 PMID: 28057087

Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039

Yuede et al (2021) Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease. J.Neurochem. 156 658 PMID: 33278025


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Literature in this Area

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5-HT Receptors Scientific Review

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Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

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