Mesulergine hydrochloride

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Cat.No. 1644 - Mesulergine hydrochloride | C18H26N4O2S.HCl | CAS No. 72786-12-0
Description: 5-HT2A and 5-HT2C antagonist. Also dopamine receptor partial agonist
Alternative Names: CU-32-085
Chemical Name: N'-[(8-α1,6-dimethylergolin-8-yl]-N,N-dimethylsulfamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.

Technical Data

M. Wt 398.95
Formula C18H26N4O2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 72786-12-0
PubChem ID 155746
InChI Key HANSYUJEPWNHIM-IVMONYBCSA-N
Smiles CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.9 100
water 1.99 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 398.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.53 mL 25.07 mL
5 mM 0.5 mL 2.51 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Marko (1984) Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 101 263 PMID: 6468500

Markstei (1983) Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 95 101 PMID: 6230246


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View all 5-HT2A Receptor Antagonists

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1 Citation for Mesulergine hydrochloride

Citations are publications that use Tocris products. Selected citations for Mesulergine hydrochloride include:

Chan et al (2015) Ergot Alkaloids (Re)generate New Leads as Antiparasitics. Neurotoxicology 9 e0004063 PMID: 26367744


Do you know of a great paper that uses Mesulergine hydrochloride from Tocris? If so please let us know.

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