MDL 11,939

Pricing Availability   Qty
Description: 5-HT2A antagonist
Chemical Name: α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol
Purity: ≥99% (HPLC)
Citations (8)
Reviews (1)
Literature (3)

Biological Activity for MDL 11,939

MDL 11,939 is an orally active 5-HT2A receptor antagonist; displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively).

Technical Data for MDL 11,939

M. Wt 295.42
Formula C20H25NO
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 107703-78-6
PubChem ID 71781

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MDL 11,939

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 14.77 50
DMSO 14.77 50

Preparing Stock Solutions for MDL 11,939

The following data is based on the product molecular weight 295.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.77 mL 33.85 mL 67.7 mL
2.5 mM 1.35 mL 6.77 mL 13.54 mL
5 mM 0.68 mL 3.39 mL 6.77 mL
25 mM 0.14 mL 0.68 mL 1.35 mL

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References for MDL 11,939

References are publications that support the biological activity of the product.

Aloyo and Harvey (2000) Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur.J.Pharmacol. 406 163 PMID: 11020478

Dudley et al (1988) Pharmacological effects of MDL 11,939: a selective, centrally acting antagonist of 5-HT2 receptors. Drug Dev.Res. 13 29

Jensen et al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-dazepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive J.Med.Chem. 56 1211 PMID: 23301527

If you know of a relevant reference for MDL 11,939, please let us know.

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Keywords: MDL 11,939, MDL 11,939 supplier, 5-HT2A, antagonist, Serotonin, Receptors, MDL11939, 0870, Tocris Bioscience

8 Citations for MDL 11,939

Citations are publications that use Tocris products. Selected citations for MDL 11,939 include:

Nagata et al (2019) Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells. Sci Rep 9 16438 PMID: 31712714

Williams et al (2012) Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by cloz. Neuropsychopharmacology 37 2285 PMID: 22692564

Halberstadt and Geyer (2010) LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor. Psychopharmacology (Berl) 208 179 PMID: 19937319

Goda et al (2013) Serotonergic hallucinogens differentially modify gamma and high frequency oscillations in the rat nucleus accumbens. Psychopharmacology (Berl) 228 271 PMID: 23525524

Do you know of a great paper that uses MDL 11,939 from Tocris? Please let us know.

Reviews for MDL 11,939

Average Rating: 5 (Based on 1 Review.)

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we used it for in vivo infusions.
By noelia weisstaub on 01/04/2018
Assay Type: In Vivo
Species: Rat

We used MDL for in vivo infusion at different regions of the brain. It works very well. It is very stable and easy to dissolve and not sticky which make it easy to infuse.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.