Potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 436.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.46 mL||57.3 mL||114.6 mL|
|1 mM||2.29 mL||11.46 mL||22.92 mL|
|2 mM||1.15 mL||5.73 mL||11.46 mL|
|10 mM||0.23 mL||1.15 mL||2.29 mL|
References are publications that support the biological activity of the product.
Wang et al (2014) The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 19 1389 PMID: 24928205
Calvo et al (2014) Preclinical analyses and phase I evaluation of LY2603618 administered in combination with pemetrexed and cisplatin in patients with advanced cancer. Invest.New Drugs 32 955 PMID: 24942404
If you know of a relevant reference for LY 2603618, please let us know.
View Related Products by Product Action
Keywords: LY 2603618, LY 2603618 supplier, LY2603618, checkpoint, Chk1, inhibitors, inhibits, potent, selective, DNA, damage, response, cell, cycle, arrest, Checkpoint, Control, Kinases, 6454, Tocris Bioscience
Citations for LY 2603618
Citations are publications that use Tocris products.
Currently there are no citations for LY 2603618. Do you know of a great paper that uses LY 2603618 from Tocris? Please let us know.
Reviews for LY 2603618
There are currently no reviews for this product. Be the first to review LY 2603618 and earn rewards!
Have you used LY 2603618?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.