Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LY 2603618 is a potent and selective Chk1 inhibitor (IC50 = 7 nM). Inhibits Chk1 autophosphorylation. Induces cell cycle arrest in the G2/M phase and induces the DNA damage response in lung cancer cells. Inhibits growth of NSCLC xenografts in mice when administered in combination with Pemetrexed (Cat.No. 6185).
LY 2603618 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 436.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.46 mL||57.3 mL||114.6 mL|
|1 mM||2.29 mL||11.46 mL||22.92 mL|
|2 mM||1.15 mL||5.73 mL||11.46 mL|
|10 mM||0.23 mL||1.15 mL||2.29 mL|
References are publications that support the biological activity of the product.
Wang et al (2014) The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells. Apoptosis 19 1389 PMID: 24928205
Calvo et al (2014) Preclinical analyses and phase I evaluation of LY2603618 administered in combination with pemet. and cisp. in patients with advanced cancer. Invest.New Drugs 32 955 PMID: 24942404
If you know of a relevant reference for LY 2603618, please let us know.
Keywords: LY 2603618, LY 2603618 supplier, LY2603618, checkpoint, Chk1, inhibitors, inhibits, potent, selective, DNA, damage, response, cell, cycle, arrest, Checkpoint, Control, Kinases, 6454, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for LY 2603618. Do you know of a great paper that uses LY 2603618 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review LY 2603618 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.