ML 9 hydrochloride

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Cat.No. 0431 - ML 9 hydrochloride | C15H17ClN2O2S.HCl | CAS No. 105637-50-1
Description: Myosin light chain kinase inhibitor
Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Compound Libraries

ML 9 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 361.29
Formula C15H17ClN2O2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 105637-50-1
PubChem ID 108047
InChI Key ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.03 25

Preparing Stock Solutions

The following data is based on the product molecular weight 361.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 11.07 mL 55.36 mL 110.71 mL
1.25 mM 2.21 mL 11.07 mL 22.14 mL
2.5 mM 1.11 mL 5.54 mL 11.07 mL
12.5 mM 0.22 mL 1.11 mL 2.21 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267 PMID: 1874276

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978

Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162


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View Related Products by Product Action

View all Myosin Light Chain Kinase Inhibitors

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4 Citations for ML 9 hydrochloride

Citations are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. PLoS One 33 11206 PMID: 23825423

Kirschstein et al (2014) Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin 35 74 PMID: 24122009

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Pharmacol Exp Ther 10 e0125974 PMID: 25933382

Gruszczynska-Biegala et al (2011) Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. PLoS One 6 e19285 PMID: 21541286


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