ML 9 hydrochloride

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Cat.No. 0431 - ML 9 hydrochloride | C15H17ClN2O2S.HCl | CAS No. 105637-50-1
Description: Myosin light chain kinase inhibitor
Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Compound Libraries

ML 9 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 361.29
Formula C15H17ClN2O2S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 105637-50-1
PubChem ID 108047
InChI Key ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.03 25

Preparing Stock Solutions

The following data is based on the product molecular weight 361.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.68 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572

Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267 PMID: 1874276

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978

Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162 PMID:


If you know of a relevant reference for ML 9 hydrochloride, please let us know.

View Related Products by Product Action

View all Myosin Light Chain Kinase Inhibitors

Keywords: Myosin light chain kinase inhibitors inhibits STIM1-plasma membrane interaction Kinases Ca2+ Binding Protein modulators Calmodulin CaM Calcium Signaling Signalling Store Operated Channels STIM-Orai ML9 hydrochloride MLCK Myosin Light Chain Kinase

2 Citations for ML 9 hydrochloride

Citations are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Pharmacol Exp Ther 10 e0125974 PMID: 25933382

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. PLoS One 33 11206 PMID: 23825423


Do you know of a great paper that uses ML 9 hydrochloride from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for ML 9 hydrochloride

Protocols

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