Autocamtide-2-related inhibitory peptide

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Cat.No. 1688 - Autocamtide-2-related inhibitory peptide | Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu | CAS No. 167114-91-2
Description: Selective CaM kinase II inhibitor
Alternative Names: AIP
Datasheet
Citations (2)
Reviews

Biological Activity

Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

Cell permeable derivative also available.

Technical Data

M. Wt 1497.76
Formula C64H116N22O19
Sequence KKALRRQEAVDAL
Storage Desiccate at -20°C
CAS Number 167114-91-2
PubChem ID 25031982
InChI Key USSJDGBHUQEJJG-HKDQSZHBSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114

Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163 PMID: 7836445

Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257 PMID: 8530441


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Keywords: Autocamtide-2-related inhibitory peptide, Autocamtide-2-related inhibitory peptide supplier, Selective, CaM, kinase, II, inhibitors, inhibits, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, AIP, Kinase, 1688, Tocris Bioscience

2 Citations for Autocamtide-2-related inhibitory peptide

Citations are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:

Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486

Grey and Burrell (2010) Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol 103 2737 PMID: 20457859


Do you know of a great paper that uses Autocamtide-2-related inhibitory peptide from Tocris? Please let us know.

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