Autocamtide-2-related inhibitory peptide
Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).
Cell permeable derivative also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1497.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.67 mL||3.34 mL||6.68 mL|
|5 mM||0.13 mL||0.67 mL||1.34 mL|
|10 mM||0.07 mL||0.33 mL||0.67 mL|
|50 mM||0.01 mL||0.07 mL||0.13 mL|
References are publications that support the biological activity of the product.
Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114
Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163 PMID: 7836445
Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257 PMID: 8530441
If you know of a relevant reference for Autocamtide-2-related inhibitory peptide, please let us know.
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2 Citations for Autocamtide-2-related inhibitory peptide
Citations are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:
Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486
Grey and Burrell (2010) Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol 103 2737 PMID: 20457859
Do you know of a great paper that uses Autocamtide-2-related inhibitory peptide from Tocris? Please let us know.
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