Autocamtide-2-related inhibitory peptide
Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).
Cell permeable derivative also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114
Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163 PMID: 7836445
Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257 PMID: 8530441
If you know of a relevant reference for Autocamtide-2-related inhibitory peptide, please let us know.
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Keywords: Autocamtide-2-related inhibitory peptide, Autocamtide-2-related inhibitory peptide supplier, Selective, CaM, kinase, II, inhibitors, inhibits, Calmodulin-Activated, calmodulin-dependent, Protein, Kinases, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, AIP, Kinase, 1688, Tocris Bioscience
2 Citations for Autocamtide-2-related inhibitory peptide
Citations are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:
Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486
Grey and Burrell (2010) Co-induction of LTP and LTD and its regulation by protein kinases and phosphatases. J Neurophysiol 103 2737 PMID: 20457859
Do you know of a great paper that uses Autocamtide-2-related inhibitory peptide from Tocris? Please let us know.
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