Autocamtide-2-related inhibitory peptide

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Cat.No. 1688 - Autocamtide-2-related inhibitory peptide | Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu | CAS No. 167114-91-2
Description: Selective CaM kinase II inhibitor
Alternative Names: AIP
Datasheet
Citations (1)

Biological Activity

Selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor (IC50 = 40 nM). Selective over PKC, PKA and CaM kinase IV (IC50 > 10 μM).

Technical Data

M. Wt 1497.76
Formula C64H116N22O19
Sequence KKALRRQEAVDAL
Storage Desiccate at -20°C
CAS Number 167114-91-2
PubChem ID 25031982
InChI Key USSJDGBHUQEJJG-HKDQSZHBSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1497.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.34 mL 6.68 mL
5 mM 0.13 mL 0.67 mL 1.34 mL
10 mM 0.07 mL 0.33 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114

Ishida and Fujisawa (1995) Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain. J.Biol.Chem. 270 2163 PMID: 7836445

Takasawa et al (1995) Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. J.Biol.Chem. 270 30257 PMID: 8530441


If you know of a relevant reference for Autocamtide-2-related inhibitory peptide, please let us know.

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View all Calcium Binding Protein Modulator Inhibitors

Keywords: Selective CaM kinase II inhibitors inhibits Calmodulin-Activated calmodulin-dependent Protein Kinases Ca2+ Binding modulators Calcium Signaling Signalling AIP Calcium Binding Protein Modulators

1 Citation for Autocamtide-2-related inhibitory peptide

Citations are publications that use Tocris products. Selected citations for Autocamtide-2-related inhibitory peptide include:

Cho et al (2012) Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci 32 14165 PMID: 23055486


Do you know of a great paper that uses Autocamtide-2-related inhibitory peptide from Tocris? If so please let us know.

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