Myosin Light Chain Kinases

Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that are currently divided into two subtypes. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19. MLCK2 is located in the striated muscle.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4310 ML 7 hydrochloride
Selective inhibitor of myosin light chain kinase
0431 ML 9 hydrochloride
Myosin light chain kinase inhibitor
1885 MLCK inhibitor peptide 18
Selective inhibitor of myosin light chain kinase
0369 W-7 hydrochloride
Myosin light chain kinase inhibitor. Calmodulin antagonist

Related Targets

    Myosin Light Chain Kinases (MLCKs) are a group of protein serine/threonine kinases that is currently divided into two subtypes, MLCK1 and MLCK2. MLCK1 is found in smooth muscle and phosphorylates myosin II regulatory light chains at Ser19, allowing myosin crossbridges to bind to actin filaments and initiate contraction.

    In addition to smooth muscle contraction, MLCK1 is involved in a diverse range of biological processes including control of endothelial and vascular permeability, growth initiation of astrocytes processes, neurotransmitter release in the sympathetic nervous system and apoptosis of fibroblasts. MLCK2 is found in striated muscle and co-localizes with phosphorylated MLC filaments to mediate skeletal and cardiac muscle contraction. MLCK3 and MLCK4 have recently been identified but are yet to be fully characterized. MLCKs are activated by Ca2+-calmodulin complexes and require Mg2+ or Ca2+ as a co-factor.

    External sources of pharmacological information for Myosin Light Chain Kinases :

      Literature for Myosin Light Chain Kinases

      Cancer

      Cancer Research Product Guide

      A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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      Kinases

      Kinases Product Listing

      A collection of over 400 products for kinase research, the listing includes inhibitors of:

      • Receptor Tyrosine Kinases
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      Myosin Light Chain Kinase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      MLCK1 Human MYLK NM_053025 Q5MYA0
      Mouse Mylk NM_139300 Q6PDN3
      Rat Mylk NM_001105874 XP_213611
      MLCK2 Human MYLK2 NM_033118 Q9H1R3
      Mouse Mylk2 NM_001081044 Q8VCR8
      Rat Mylk2 NM_057209 P20689
      MLCK3 Human MYLK3 NM_182493 Q32MK0
      Mouse Mylk3 NM_175441 Q3UIZ8
      Rat Mylk3 NM_001110810 XP_214645
      MLCK4 Human MYLK4 NM_001012418 Q86YV6